ArticleJournal of diabetes research2014
Glyoxylate, a new marker metabolite of type 2 diabetes.
Article in Journal of diabetes research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06959043 (Therapeutic Strategies for Type 2 Diabetes Based on Lifestyle Changes), which is not on this map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Therapeutic Strategies for Type 2 Diabetes Based on Lifestyle Changes: Plant-based Diet and Physical Exercise
Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Coregulated metabolite networks associated with global protein crotonylation are central pathophysiological processes in prediabetes and diabetes.medRxiv : the preprint server for health sciences · 2026Article
- The prairie vole gut-brain-microbiota-axis: a narrative review.Gut microbiome (Cambridge, England) · 2026Review
- The effect of the administration form of antibiotic therapy on the gut microbiome in patients with infected diabetic foot ulcers - DFIATIM trial.BMC microbiology · 2025Article
- Chemoselective Stabilized Triphenylphosphonium Probes for Capturing Reactive Carbonyl Species and Regenerating Covalent Inhibitors with Acrylamide Warheads in Cellulo.Journal of the American Chemical Society · 2025Article
- Glucose-Sensing Carbohydrate Response Element-Binding Protein in the Pathogenesis of Diabetic Retinopathy.Cells · 2025Article
- Glucose-Sensing ChREBP Protein in the Pathogenesis of Dia-betic Retinopathy.bioRxiv : the preprint server for biology · 2024Article
- Review
- Clinicopathologic Characteristics, Etiologies, and Outcome of Secondary Oxalate Nephropathy.Mayo Clinic proceedings · 2024Article
- Application of Clinical Blood Metabogram to Type 2 Diabetes Mellitus.Metabolites · 2024Article
- Essential oil supplementation improves insulin sensitivity and modulates the plasma metabolome of hyperinsulinemic horses.Frontiers in veterinary science · 2024Article
- Oxalate Nephropathy and the Mechanism of Oxalate-Induced Kidney Injury.Kidney diseases (Basel, Switzerland) · 2023Review
- Identification of Serum Metabolites as Prognostic Biomarkers Following Spinal Cord Injury: A Pilot Study.Metabolites · 2023Article
- Intramuscular administration of glyoxylate rescues swine from lethal cyanide poisoning and ameliorates the biochemical sequalae of cyanide intoxication.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Microbiome and Metabolome Variation as Indicator of Social Stress in Female Prairie Voles.International journal of molecular sciences · 2023Article
- Application of Metabolomics and Traditional Chinese Medicine for Type 2 Diabetes Mellitus Treatment.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- A bacterial enzyme may correct 2-HG accumulation in human cancers.Frontiers in oncology · 2023Article
- Longitudinal metabolomic profiles reveal sex-specific adjustments to long-duration spaceflight and return to Earth.Cellular and molecular life sciences : CMLS · 2022Article
- Acute oxalate nephropathy: A potential cause of acute kidney injury in diabetes mellitus-A case series from a single center.Frontiers in medicine · 2022Article
- Liquid-Chromatographic Methods for Carboxylic Acids in Biological Samples.Molecules (Basel, Switzerland) · 2020Review
- Metabolomics reveals the impact of Type 2 diabetes on local muscle and vascular responses to ischemic stress.Clinical science (London, England : 1979) · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes (T2D) is characterized by a variety of metabolic impairments that are closely linked to nonenzymatic glycation reactions of proteins and peptides resulting in advanced glycation end-products (AGEs). Reactive aldehydes derived from sugars play an important role in the generation of AGEs. Using metabolite profiling to characterize human plasma from diabetic versus nondiabetic subjects we observed in a recent study that the reactive aldehyde glyoxylate was increased before high levels of plasma glucose, typical for a diabetic condition, could be measured. Following this observation, we explored the relevance of increased glyoxylate in diabetic subjects and in diabetic C57BLKS/J-Lepr (db/db (-/-)) mice in the pathophysiology of diabetes. A retrospective study using samples of long-term blood donors revealed that glyoxylate levels unlike glucose levels became significantly elevated up to 3 years prior to diabetes diagnosis (difference to control P = 0.034). Elevated glyoxylate levels impact on newly identified mechanisms linking hyperglycemia and AGE production with diabetes-associated complications such as diabetic nephropathy. Glyoxylate in its metabolic network may serve as an early marker in diabetes diagnosis with predictive qualities for associated complications and as potential to guide the development of new antidiabetic therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.