Evidence map›Paper›PMID 25525560›Full record

ArticleJournal of clinical & cellular immunology2014

Imaging Neuroinflammation - from Bench to Bedside.

Benjamin Pulli, John W Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical & cellular immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Nucleus accumbens cytoarchitecture predicts weight gain in children.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  9. Progressive Supranuclear Palsy and Statin Use.Movement disorders : official journal of the Movement Disorder Society · 2020
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Theranostics · 2018
    Review
  15. Article
  16. Review
  17. Review
  18. In Vivo Imaging of Human Neuroinflammation.ACS chemical neuroscience · 2016
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Benjamin PulliCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA.
John W ChenCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA.

Funding

Myeloperoxidase, imaging biomarker and treatment target for multiple sclerosisR01NS070835 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, JOHN W · 2010 to 2014
$1.9M
Imaging and Treating Inflammation in Stroke by Targeting MyeloperoxidaseR01NS072167 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, JOHN W · 2010 to 2014
$1.8M
NINDS NIH HHS R01 NS070835NINDS NIH HHS R01 NS072167
6 · The paper itself

Abstract

Neuroinflammation plays a central role in a variety of neurological diseases, including stroke, multiple sclerosis, Alzheimer's disease, and malignant CNS neoplasms, among many other. Different cell types and molecular mediators participate in a cascade of events in the brain that is ultimately aimed at control, regeneration and repair, but leads to damage of brain tissue under pathological conditions. Non-invasive molecular imaging of key players in the inflammation cascade holds promise for identification and quantification of the disease process before it is too late for effective therapeutic intervention. In this review, we focus on molecular imaging techniques that target inflammatory cells and molecules that are of interest in neuroinflammation, especially those with high translational potential. Over the past decade, a plethora of molecular imaging agents have been developed and tested in animal models of (neuro)inflammation, and a few have been translated from bench to bedside. The most promising imaging techniques to visualize neuroinflammation include MRI, positron emission tomography (PET), single photon emission computed tomography (SPECT), and optical imaging methods. These techniques enable us to image adhesion molecules to visualize endothelial cell activation, assess leukocyte functions such as oxidative stress, granule release, and phagocytosis, and label a variety of inflammatory cells for cell tracking experiments. In addition, several cell types and their activation can be specifically targeted

Indexed as

BrainCNSInflammationMolecular imagingMRINeuroinflammationPET

Identifiers

PMID25525560
PMCPMC4266918

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.