Evidence map›Paper›PMID 25525507›Full record

ArticleNanomaterials (Basel, Switzerland)2014

Carbon Nanotubes and Chronic Granulomatous Disease.

Barbara P Barna, Marc A Judson, Mary Jane Thomassen

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Current research trends of nanomedicines.Acta pharmaceutica Sinica. B · 2023
    Review
  3. Environmental Risk Factors for Sarcoidosis.Frontiers in immunology · 2020
    Review
  4. Carbon nanotubes: Evaluation of toxicity at biointerfaces.Journal of pharmaceutical analysis · 2019
    Review
  5. Alveolar Macrophage ABCG1 Deficiency Promotes Pulmonary Granulomatous Inflammation.American journal of respiratory cell and molecular biology · 2019
    Article
  6. Article
  7. Article
  8. Article
  9. Challenges and Advances in Nanotoxicology.Nanomaterials (Basel, Switzerland) · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Barbara P BarnaDivision of Pulmonary, Critical Care and Sleep Medicine, East Carolina University, Brody Medical Sciences Building, 600 Moye Blvd. Rm. 3E-149, Greenville, NC 27834, USA.
Marc A JudsonDivision of Pulmonary and Critical Care Medicine, Albany Medical College, MC-91, 47 New Scotland Avenue, Albany, NY 12208, USA.
Mary Jane ThomassenDivision of Pulmonary, Critical Care and Sleep Medicine, East Carolina University, Brody Medical Sciences Building, 600 Moye Blvd. Rm. 3E-149, Greenville, NC 27834, USA.

Funding

PPARgamma Dysfunction in SarcoidoisR21HL077652 · NHLBI · EAST CAROLINA UNIVERSITY · PI THOMASSEN, MARY JANE · 2004 to 2005
$405k
Chronic Granulomatous Lung Inflammation Elicited by Carbon NanotubesR15ES022462 · NIEHS · EAST CAROLINA UNIVERSITY · PI THOMASSEN, MARY JANE · 2013 to 2013
$368k
NHLBI NIH HHS R21 HL077652NIEHS NIH HHS R15 ES022462
6 · The paper itself

Abstract

Use of nanomaterials in manufactured consumer products is a rapidly expanding industry and potential toxicities are just beginning to be explored. Combustion-generated multiwall carbon nanotubes (MWCNT) or nanoparticles are ubiquitous in non-manufacturing environments and detectable in vapors from diesel fuel, methane, propane, and natural gas. In experimental animal models, carbon nanotubes have been shown to induce granulomas or other inflammatory changes. Evidence suggesting potential involvement of carbon nanomaterials in human granulomatous disease, has been gathered from analyses of dusts generated in the World Trade Center disaster combined with epidemiological data showing a subsequent increase in granulomatous disease of first responders. In this review we will discuss evidence for similarities in the pathophysiology of carbon nanotube-induced pulmonary disease in experimental animals with that of the human granulomatous disease, sarcoidosis.

Indexed as

alveolar macrophagescarbon nanotubessarcoidosis

Identifiers

PMID25525507
PMCPMC4267561

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.