ArticleNeuropsychiatric disease and treatment2014
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia.
Article in Neuropsychiatric disease and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Findings on Impact of Circadian Genes and Bipolar Disorder: A Bibliometric Analysis From 1996 to 2024.Brain and behavior · 2026Article
- Phenome-wide screening of the putative causal determinants of bipolar affective disorder using genetic data.PloS one · 2026Article
- Article
- Sleep and circadian disruption in bipolar disorders: From psychopathology to digital phenotyping in clinical practice.Psychiatry and clinical neurosciences · 2024Review
- The influence of PER3 VNTR genotypes on the age of onset in a group of bipolar I disorder patients: an exploratory study.International journal of bipolar disorders · 2024Article
- Insomnia and circadian rhythm: a bibliometrics study and visualization analysisFrontiers in neurology · 2023Article
- Neurobiological and behavioral mechanisms of circadian rhythm disruption in bipolar disorder: A critical multi-disciplinary literature review and agenda for future research from the ISBD task force on chronobiology.Bipolar disorders · 2022Review
- Sleep and Circadian Rhythm Disorder in Bipolar Affective Disorder.Current topics in behavioral neurosciences · 2021Article
- Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective.Psychiatry investigation · 2020Article
- A Topological Cluster of Differentially Regulated Genes in Mice Lacking PER3.Frontiers in molecular neuroscience · 2020Article
- Sleep and circadian rhythms in health and disease: a complex interplay.European archives of psychiatry and clinical neuroscience · 2019Article
- Genetic influence alters the brain synchronism in perception and timing.Journal of biomedical science · 2018Review
- Genetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorder.Psychiatry investigation · 2017Article
- Circadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety.Scientific reports · 2017Article
- Human genetics and sleep behavior.Current opinion in neurobiology · 2017Review
- Clock Genes and Altered Sleep-Wake Rhythms: Their Role in the Development of Psychiatric Disorders.International journal of molecular sciences · 2017Article
- Potential biomarkers for bipolar disorder: Where do we stand?The Indian journal of medical research · 2017Review
- Analysis of 23andMe antidepressant efficacy survey data: implication of circadian rhythm and neuroplasticity in bupropion response.Translational psychiatry · 2016Article
- Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature.International journal of endocrinology · 2016Review
- Personalized medicine for pathological circadian dysfunctions.Frontiers in pharmacology · 2015Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSleep-wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India.
methodsBlood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers.
resultsAn increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08-2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ (2)=4.634; P<0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls.
conclusionThe occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group.
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