ArticlePatient preference and adherence2014
Efficacy of a brief multifactorial adherence-based intervention in reducing blood pressure: a randomized clinical trial.
Article in Patient preference and adherence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07397260 (Effects of Manually Recorded or Automatically Transmitted Home Blood Pressures With or Without Automated Patient Feedback on Hypertension Care), which is not on this map. Cited by 14 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Manually Recorded or Automatically Transmitted Home Blood Pressures With or Without Automated Patient Feedback on Hypertension Care
Who cites it
14 citing papers in PubMed, 6 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Medication Adherence and Contributing Factors in Patients with Heart Failure Within the Middle East: A Systematic Review.Global heart · 2025Pooled it
- The short and long-term efficacy of nurse-led interventions for improving blood pressure control in people with hypertension in primary care settings: a systematic review and meta-analysis.BMC primary care · 2024Pooled it
- The effect of integrated health care in patients with hypertension and diabetes: a systematic review and meta-analysis.BMC health services research · 2022Pooled it
- Effectiveness of nursing case management versus usual care for blood pressure control in adults with hypertension: a systematic review.Investigacion y educacion en enfermeria · 2021Pooled it
- Self-monitoring of Blood Pressure in Patients With Hypertension-Related Multi-morbidity: Systematic Review and Individual Patient Data Meta-analysis.American journal of hypertension · 2020Pooled it
- Self-monitoring of blood pressure in hypertension: A systematic review and individual patient data meta-analysis.PLoS medicine · 2017Pooled it
- Transferability of nurse-led interventions for cardiovascular health across diverse nursing roles in primary and community settings: Practice implications and solutions from a scoping review.American journal of preventive cardiology · 2026Review
- Article
- Pharmacists delivering hypertension care services: a systematic review and meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2025Article
- Health Techequity: Opportunities for Digital Health Innovations to Improve Equity and Diversity in Cardiovascular Care.Current cardiovascular risk reports · 2023Review
- A clinical trial on the effect of a multifaceted intervention on blood pressure control and medication adherence in patients with uncontrolled hypertension.ARYA atherosclerosis · 2019Article
- Article
- Hydroxychloroquine Blood Levels in Systemic Lupus Erythematosus: Clarifying Dosing Controversies and Improving Adherence.The Journal of rheumatology · 2015Article
- Can drugs work in patients who do not take them? The problem of non-adherence in resistant hypertension.Current hypertension reports · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLowering blood pressure (BP) by antihypertensive (AHT) drugs reduces the risks of cardiovascular events, stroke, and total mortality. However, poor adherence to AHT medications reduces their effectiveness and increases the risk of adverse events.
objectiveTo evaluate the effectiveness of a multifactorial adherence-based intervention in a primary care setting in lowering BP. METHODS/
designMulticenter parallel randomized controlled trial. Thirty two nurses in 28 primary care centers of three Spanish regions. Patients aged 18-80 years, taking AHT drugs with uncontrolled BP (n=221) were randomized to a control group (usual care) or a multifactorial adherence-based intervention including nurse-led motivational interviews, pill reminders, family support, BP self-recording, and simplification of the dosing regimen by a pharmacist.
main outcome measuresThe primary outcome was 12-month blinded measure of systolic BP (mean of three measurements). The secondary outcomes were 12-month diastolic BP and proportion of patients with adequately controlled BP.
resultsOne hundred and fourteen patients were allocated to the intervention group and 109 to the control group. At 12 months, 212 (89%) participants completed the study. The systolic BP in the intervention group was 151.3 versus 153.7 in the control group (P=0.294). The diastolic BP did not differ between groups (83.4 versus 83.6). Of the patients in the control group, 9.2% achieved BP control versus a 15.8% in the intervention group. The relative risk for achieving BP control was 1.72 (95% confidence interval: 0.83-3.56).
conclusionA multifactorial intervention based on improving adherence in patients with uncontrolled hypertension failed to find evidence of effectiveness in lowering systolic BP.
trial registrationISRCTN21229328.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.