ArticleScience (New York, N.Y.)2014
RETRACTED: MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses.
Article in Science (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 68 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 105 citations in OpenAlex.
- Human Endogenous Retroviruses and Diseases.MedComm · 2025Review
- Identification of conserved T cell epitopes and flanking amino acid mutants of endogenous retrovirus Gag antigen in nonobese diabetic mice.ImmunoHorizons · 2025Article
- Activation of lnc-ALVE1-AS1 inhibited ALV-J replication through triggering the TLR3 pathway in chicken macrophage like cell line.Veterinary research communications · 2023Article
- Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases.Zoological research · 2023Review
- HIV-1-induced type I IFNs promote viral latency in macrophages.Journal of leukocyte biology · 2022Article
- Why Should We Consider Potential Roles of Oral Bacteria in the Pathogenesis of Sjögren Syndrome?Immune network · 2022Review
- Early IgE Production Is Linked with Extrafollicular B- and T-Cell Activation in Low-Dose Allergy Model.Vaccines · 2022Article
- Making sense of IL-6 signalling cues in pathophysiology.FEBS letters · 2022Review
- Adoptive cell therapy with tumor-specific Th9 cells induces viral mimicry to eliminate antigen-loss-variant tumor cells.Cancer cell · 2021Article
- Endogenous Feline Leukemia Virus (FeLV) siRNA Transcription May Interfere with Exogenous FeLV Infection.Journal of virology · 2021Article
- Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency.iScience · 2021Article
- Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence.Nature genetics · 2021Article
- Shoulder position and handedness differentially affect excitability and intracortical inhibition of hand muscles.Experimental brain research · 2021Article
- Endogenous retrovirus Gag antigen and its gene variants are unique autoantigens expressed in the pancreatic islets of non-obese diabetic mice.Immunology letters · 2020Article
- The Sophisticated Transcriptional Response Governed by Transposable Elements in Human Health and Disease.International journal of molecular sciences · 2020Review
- SETDB1 Overexpression Sets an Intertumoral Transcriptomic Divergence in Non-small Cell Lung Carcinoma.Frontiers in genetics · 2020Article
- Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling.Nature immunology · 2019Article
- Type of RNA Packed in VLPs Impacts IgG Class Switching-Implications for an Influenza Vaccine Design.Vaccines · 2019Article
- TMEM173 variants and potential importance to human biology and disease.Genes and immunity · 2019Review
- Transposable element dysregulation in systemic lupus erythematosus and regulation by histone conformation and Hsp90.Clinical immunology (Orlando, Fla.) · 2018Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2017-10-26Results Not Reproducible ·
- Commented on by
- Retracted
Authors and funding
19 authors at 3 institutions in 2 countries.
Funding
Abstract
Multivalent molecules with repetitive structures including bacterial capsular polysaccharides and viral capsids elicit antibody responses through B cell receptor (BCR) crosslinking in the absence of T cell help. We report that immunization with these T cell-independent type 2 (TI-2) antigens causes up-regulation of endogenous retrovirus (ERV) RNAs in antigen-specific mouse B cells. These RNAs are detected via a mitochondrial antiviral signaling protein (MAVS)-dependent RNA sensing pathway or reverse-transcribed and detected via the cGAS-cGAMP-STING pathway, triggering a second, sustained wave of signaling that promotes specific immunoglobulin M production. Deficiency of both MAVS and cGAS, or treatment of MAVS-deficient mice with reverse transcriptase inhibitors, dramatically inhibits TI-2 antibody responses. These findings suggest that ERV and two innate sensing pathways that detect them are integral components of the TI-2 B cell signaling apparatus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.