ArticleThe Journal of infectious diseases2015
Host-pathogen Interaction at the Intestinal Mucosa Correlates With Zoonotic Potential of Streptococcus suis.
Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Identification ofVirulence · 2021Pooled it
- Streptococcus suis Meningitis: A Systematic Review and Meta-analysis.PLoS neglected tropical diseases · 2015Pooled it
- Innate immune response to Streptococcus suis infection: advances and future challenges.Veterinary research · 2026Review
- A conserved glycan motif induces broadly reactive functional antibodies against the zoonotic pathogenScience advances · 2026Article
- Serotype 2 Streptococcus suis growth inhibition mediated by intraspecies contact-dependent mechanism.Scientific reports · 2025Article
- Population Genomics, Virulence Traits, and Antimicrobial Resistance ofMicroorganisms · 2025Article
- The cadDX operon contributes to cadmium resistance, oxidative stress resistance, and virulence in zoonotic streptococci.Veterinary research · 2024Article
- Article
- Antiviral Drug Candidate Repositioning forBiomedicines · 2024Article
- Translocation across a human enteroid monolayer by zoonoticiScience · 2024Article
- Characterization of pig tonsils as niches for the generation of Streptococcus suis diversity.Veterinary research · 2024Article
- A novel aquaporin Aagp contributes toVirulence · 2023Article
- A critical review on experimental Streptococcus suis infection in pigs with a focus on clinical monitoring and refinement strategies.BMC veterinary research · 2023Review
- The antimicrobial systems ofVirulence · 2022Article
- Piglet innate immune response to Streptococcus suis colonization is modulated by the virulence of the strain.Veterinary research · 2021Article
- Genome analysis provides insight into hyper-virulence of Streptococcus suis LSM178, a human strain with a novel sequence type 1005.Scientific reports · 2021Article
- A rare case of meningitis and septicemia caused by Streptococcus suis in a woman without a history of live pig contact or eating raw pork.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Short-chain fatty acid administration via water acidifier improves feed efficiency and modulates fecal microbiota in weaned piglets.Journal of animal science · 2021Article
- The type II histidine triad protein HtpsC facilitates invasion of epithelial cells by highly virulent Streptococcus suis serotype 2.Journal of microbiology (Seoul, Korea) · 2021Article
- The global emergence of a novel Streptococcus suis clade associated with human infections.EMBO molecular medicine · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundStreptococcus suis has emerged as an important cause of bacterial meningitis in adults. The ingestion of undercooked pork is a risk factor for human S. suis serotype 2 (SS2) infection. Here we provide experimental evidence indicating that the gastrointestinal tract is an entry site of SS2 infection.
methodsWe developed a noninvasive in vivo model to study oral SS2 infection in piglets. We compared in vitro interaction of S. suis with human and porcine intestinal epithelial cells (IEC).
resultsTwo out of 15 piglets showed clinical symptoms compatible with S. suis infection 24-48 hours after ingestion of SS2. SS2 was detected in mesenteric lymph nodes of 40% of challenged piglets. SS2 strains isolated from patients showed significantly higher adhesion to human IEC compared to invasive strains isolated from pigs. In contrast, invasive SS9 strains showed significantly higher adhesion to porcine IEC. Translocation across human IEC, which occurred predominately via a paracellular route, was significantly associated with clonal complex 1, the predominant zoonotic genotype. Adhesion and translocation were dependent on capsular polysaccharide production.
conclusionsSS2 should be considered a food-borne pathogen. S. suis interaction with human and pig IEC correlates with S. suis serotype and genotype, which can explain the zoonotic potential of SS2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.