Evidence map›Paper›PMID 25525033›Full record

ArticleCancer gene therapy2015

Analysis of glioblastoma tumor coverage by oncolytic virus-loaded neural stem cells using MRI-based tracking and histological reconstruction.

R A Morshed, M Gutova, J Juliano, M E Barish, A Hawkins-Daarud, D Oganesyan, K Vazgen, T Yang, A Annala, A U Ahmed and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer gene therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 53 citations in OpenAlex.

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  17. Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

R A MorshedThe Brain Tumor Center, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA.
M GutovaDepartment of Neuroscience, City of Hope National Medical Center, Beckman Research Institute, Duarte, CA, USA.
J JulianoNorthwestern Brain Tumor Institute, Robert H. Lurie Cancer Center, Chicago, IL, USA.
M E Barish1] Department of Neuroscience, City of Hope National Medical Center, Beckman Research Institute, Duarte, CA, USA [2] Division of Neurosurgery, City of Hope National Medical Center, Beckman Research Institute, Duarte, CA, USA [3] Department of Radiology, Children's Hospital of Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
A Hawkins-DaarudNorthwestern Brain Tumor Institute, Robert H. Lurie Cancer Center, Chicago, IL, USA.
D OganesyanDepartment of Radiology, Children's Hospital of Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
K VazgenDepartment of Radiology, Children's Hospital of Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
T YangDepartment of Radiology, Children's Hospital of Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
A AnnalaDepartment of Neuroscience, City of Hope National Medical Center, Beckman Research Institute, Duarte, CA, USA.ORCID 0000000259676596
A U AhmedThe Brain Tumor Center, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA.
K S Aboody1] Department of Neuroscience, City of Hope National Medical Center, Beckman Research Institute, Duarte, CA, USA [2] Division of Neurosurgery, City of Hope National Medical Center, Beckman Research Institute, Duarte, CA, USA.
K R SwansonNorthwestern Brain Tumor Institute, Robert H. Lurie Cancer Center, Chicago, IL, USA.
R A MoatsDepartment of Radiology, Children's Hospital of Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
M S LesniakThe Brain Tumor Center, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA.
City Of Hope National Medical Center · USUniversity of Southern California · USNorthwestern Medicine · USUniversity of Chicago · US

Funding

Neural Stem Cell Based Virotherapy for Malignant GliomaU01NS069997 · NINDS · UNIVERSITY OF CHICAGO · PI YAMINI, BAKHTIAR · 2010 to 2014
$6.1M
NINDS NIH HHS U01 NS069997
6 · The paper itself

Abstract

In preclinical studies, neural stem cell (NSC)-based delivery of oncolytic virus has shown great promise in the treatment of malignant glioma. Ensuring the success of this therapy will require critical evaluation of the spatial distribution of virus after NSC transplantation. In this study, the patient-derived GBM43 human glioma line was established in the brain of athymic nude mice, followed by the administration of NSCs loaded with conditionally replicating oncolytic adenovirus (NSC-CRAd-S-pk7). We determined the tumor coverage potential of oncolytic adenovirus by examining NSC distribution using magnetic resonance (MR) imaging and by three-dimensional reconstruction from ex vivo tissue specimens. We demonstrate that unmodified NSCs and NSC-CRAd-S-pk7 exhibit a similar distribution pattern with most prominent localization occurring at the tumor margins. We were further able to visualize the accumulation of these cells at tumor sites via T2-weighted MR imaging as well as the spread of viral particles using immunofluorescence. Our analyses reveal that a single administration of oncolytic virus-loaded NSCs allows for up to 31% coverage of intracranial tumors. Such results provide valuable insights into the therapeutic potential of this novel viral delivery platform.

Indexed as

Cell TrackingMagnetic Resonance ImagingAdenoviridaeAnimalsBrainCell Line, TumorDisease Models, AnimalGenetic VectorsGene Transfer TechniquesGlioblastomaHumansMiceNeural Stem CellsOncolytic VirusesTransduction, GeneticTumor Burden

Identifiers

PMID25525033
PMCPMC4293243
OpenAlexW2045161060

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.