ArticleHippocampus2015
The organization of AMPA receptor subunits at the postsynaptic membrane.
Article in Hippocampus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Paradoxical Expression of Ionotropic Glutamate Receptors in Leucocytes.Clinical reviews in allergy & immunology · 2026Article
- Review
- Quantification of AMPA receptor subunits and RNA editing-related proteins in the J20 mouse model of Alzheimer's disease by capillary western blotting.Frontiers in molecular neuroscience · 2023Article
- Framework for internal sensation of pleasure using constraints from disparate findings in nucleus accumbens.World journal of psychiatry · 2021Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Article
- Research Progress on Alzheimer's Disease and Resveratrol.Neurochemical research · 2020Review
- Therapeutic Effect of Agmatine on Neurological Disease: Focus on Ion Channels and Receptors.Neurochemical research · 2019Review
- Functional organization of postsynaptic glutamate receptors.Molecular and cellular neurosciences · 2018Review
- Differentiation and Characterization of Excitatory and Inhibitory Synapses by Cryo-electron Tomography and Correlative Microscopy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Distinct Phenotypes ofFrontiers in molecular neuroscience · 2018Review
- The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells.Brain structure & function · 2017Article
- Article
- Novel Applications of Magnetic Cell Sorting to Analyze Cell-Type Specific Gene and Protein Expression in the Central Nervous System.PloS one · 2016Article
- Quantitative mass spectrometry measurements reveal stoichiometry of principal postsynaptic density proteins.Journal of proteome research · 2015Article
- A framework for the first-person internal sensation of visual perception in mammals and a comparable circuitry for olfactory perception in Drosophila.SpringerPlus · 2015Article
- A pressure-reversible cellular mechanism of general anesthetics capable of altering a possible mechanism for consciousness.SpringerPlus · 2015Article
- Neurological disorders of COVID-19 can be explained in terms of both "loss and gain of function" states of a solution for the nervous system.Brain circulationArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
AMPA receptors are the principal mediators of excitatory synaptic transmission in the mammalian central nervous system. The subunit composition of these tetrameric receptors helps to define their functional properties, and may also influence the synaptic trafficking implicated in long-term synaptic plasticity. However, the organization of AMPAR subunits within the synapse remains unclear. Here, we use postembedding immunogold electron microscopy to study the synaptic organization of AMPAR subunits in stratum radiatum of CA1 hippocampus in the adult rat. We find that GluA1 concentrates away from the center of the synapse, extending at least 25 nm beyond the synaptic specialization; in contrast, GluA3 is uniformly distributed along the synapse, and seldom extends beyond its lateral border. The fraction of extrasynaptic GluA1 is markedly higher in small than in large synapses; no such effect is seen for GluA3. These observations imply that different kinds of AMPARs are differently trafficked to and/or anchored at the synapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.