Evidence map›Paper›PMID 25524774›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2015

Cluster of differentiation 43 deficiency in leukocytes leads to reduced atherosclerosis--brief report.

Svenja Meiler, Yvonne Baumer, Sara McCurdy, Bog-Hieu Lee, Shiro Kitamoto, William A Boisvert

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Chitosan from Crabs (Pathophysiology : the official journal of the International Society for Pathophysiology · 2021
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  4. Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Svenja MeilerFrom the Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu (S.M., Y.B., S.M., W.A.B.); Department of Food and Nutrition, School of Food Science and Technology, Chung-Ang University, Seoul, Korea (B.-H.L.); Departments of Cardiovascular Medicine and Advanced Therapeutics for Cardiovascular Diseases, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (S.K.); and Kazan Federal University, Kazan, Russia (W.A.B.).
Yvonne BaumerFrom the Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu (S.M., Y.B., S.M., W.A.B.); Department of Food and Nutrition, School of Food Science and Technology, Chung-Ang University, Seoul, Korea (B.-H.L.); Departments of Cardiovascular Medicine and Advanced Therapeutics for Cardiovascular Diseases, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (S.K.); and Kazan Federal University, Kazan, Russia (W.A.B.).
Sara McCurdyFrom the Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu (S.M., Y.B., S.M., W.A.B.); Department of Food and Nutrition, School of Food Science and Technology, Chung-Ang University, Seoul, Korea (B.-H.L.); Departments of Cardiovascular Medicine and Advanced Therapeutics for Cardiovascular Diseases, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (S.K.); and Kazan Federal University, Kazan, Russia (W.A.B.).
Bog-Hieu LeeFrom the Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu (S.M., Y.B., S.M., W.A.B.); Department of Food and Nutrition, School of Food Science and Technology, Chung-Ang University, Seoul, Korea (B.-H.L.); Departments of Cardiovascular Medicine and Advanced Therapeutics for Cardiovascular Diseases, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (S.K.); and Kazan Federal University, Kazan, Russia (W.A.B.).
Shiro KitamotoFrom the Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu (S.M., Y.B., S.M., W.A.B.); Department of Food and Nutrition, School of Food Science and Technology, Chung-Ang University, Seoul, Korea (B.-H.L.); Departments of Cardiovascular Medicine and Advanced Therapeutics for Cardiovascular Diseases, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (S.K.); and Kazan Federal University, Kazan, Russia (W.A.B.).
William A BoisvertFrom the Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu (S.M., Y.B., S.M., W.A.B.); Department of Food and Nutrition, School of Food Science and Technology, Chung-Ang University, Seoul, Korea (B.-H.L.); Departments of Cardiovascular Medicine and Advanced Therapeutics for Cardiovascular Diseases, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (S.K.); and Kazan Federal University, Kazan, Russia (W.A.B.). wab@hawaii.edu.
Kyushu University · JPChung-Ang University · KR

Funding

WORLDWIDE EPIDEMIOLOGY &EPIZOOTIOLOGY OF HANTAVIRUSG12RR003061 · NCRR · UNIVERSITY OF HAWAII AT MANOA · PI COUVILLON, PATRICIA A · 1986 to 2011
$32.3M
UHI COBRE: SOLID STATE NMR STUDIES OF MINERALIZED ELASTINP20RR016453 · NCRR · UNIVERSITY OF HAWAII AT MANOA · PI SHOHET, RALPH V. · 2001 to 2011
$21.2M
RESEARCH DESIGN, BIOSTATISTICS AND RESEARCH ETHICS COREG12MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI BERRY, MARLA J · 2012 to 2016
$13.0M
Pacific Center for Emerging Infectious Diseases ResearchP20GM103516 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI YANAGIHARA, RICHARD · 2012 to 2014
$6.1M
Pilot Project ProgramP30GM103341 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI SHOHET, RALPH V. · 2012 to 2016
$5.5M
Training in Cardiovascular Research at the University of HawaiiT32HL115505 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI Michelle D Tallquist · 2012 to 2026
$3.8M
Innate Immunity and Allergy: Modulation by CTLA4R01HL081663 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FINN, PATRICIA W · 2005 to 2008
$2.0M
Anti-inflammatory Cytokines in AtherosclerosisR01HL075677 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI BOISVERT, WILLIAM A · 2005 to 2008
$1.6M
Rho kinase in immune-mediated atherosclerosisR01HL081863 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI BOISVERT, WILLIAM A · 2007 to 2010
$1.6M
NCRR NIH HHS G12 RR003061NCRR NIH HHS G12RR003061NCRR NIH HHS P20 RR016453NCRR NIH HHS P20RR016453NHLBI NIH HHS R01 HL075677NHLBI NIH HHS R01HL075677NHLBI NIH HHS R01 HL081663NHLBI NIH HHS R01 HL081863NHLBI NIH HHS R01HL81863NHLBI NIH HHS T32 HL115505NIGMS NIH HHS P20 GM103516NIGMS NIH HHS P20GM103516NIGMS NIH HHS P30 GM103341NIMHD NIH HHS G12 MD007601NIMHD NIH HHS G12MD007601
6 · The paper itself

Abstract

objectiveThe aim of this study was to investigate the role of cluster of differentiation 43 (CD43), an integral membrane glycoprotein with both proadhesive and antiadhesive activities, in atherosclerosis. APPROACH AND

resultsLow-density lipoprotein receptor-deficient mice were lethally irradiated and reconstituted with either bone marrow from CD43(-/-) mice or from wild-type controls. We found that mice lacking the CD43 on their leukocytes had significantly less severe atherosclerosis and that, contrary to our expectation, macrophage infiltration into the vessel wall was not affected by the lack of CD43 in the leukocytes. However, we found that CD43 mediates cholesterol homeostasis in macrophages by facilitating cholesterol efflux. This resulted in a significant reduction in storage of cholesterol in the aorta of mice lacking CD43 in the leukocytes.

conclusionsCD43 may be an important mediator of macrophage lipid homeostasis, thereby affecting macrophage foam cell formation and ultimately atherosclerotic plaque development.

Indexed as

AnimalsAortaAortic DiseasesAtherosclerosisCells, CulturedCholesterolDisease Models, AnimalDown-RegulationLeukocytesLeukosialinMacrophagesMaleMice, Inbred C57BLMice, KnockoutPlaque, AtheroscleroticReceptors, LDLCholesterolLeukosialinReceptors, LDLSpn protein, mouseatherosclerosismacrophages

Identifiers

PMID25524774
PMCPMC4304996
OpenAlexW2090032308

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.