Evidence map›Paper›PMID 25524657›Full record

ArticleEuropean journal of oncology nursing : the official journal of European Oncology Nursing Society2015

Associations between catecholaminergic, GABAergic, and serotonergic genes and self-reported attentional function in oncology patients and their family caregivers.

John D Merriman, Bradley E Aouizerat, Janine K Cataldo, Laura B Dunn, Kord Kober, Dale J Langford, Claudia West, Bruce A Cooper, Steven M Paul, Christine Miaskowski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of oncology nursing : the official journal of European Oncology Nursing Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

John D MerrimanSchool of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, USA. Electronic address: jdm150@pitt.edu.
Bradley E AouizeratSchool of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, USA; Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Box 0794, San Francisco, CA 94143-0794, USA. Electronic address: bradley.aouizerat@nursing.ucsf.edu.
Janine K CataldoSchool of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, USA. Electronic address: janine.cataldo@nursing.ucsf.edu.
Laura B DunnSchool of Medicine, University of California, San Francisco, 513 Parnassus Avenue, Box 0410, San Francisco, CA 94143-0410, USA. Electronic address: laura.dunn@ucsf.edu.
Kord KoberSchool of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, USA. Electronic address: kord.kober@nursing.ucsf.edu.
Dale J LangfordSchool of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, USA. Electronic address: dale.langford@nursing.ucsf.edu.
Claudia WestSchool of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, USA. Electronic address: claudia.west@nursing.ucsf.edu.
Bruce A CooperSchool of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, USA. Electronic address: bruce.cooper@nursing.ucsf.edu.
Steven M PaulSchool of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, USA. Electronic address: steven.paul@nursing.ucsf.edu.
Christine MiaskowskiSchool of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143-0610, USA. Electronic address: chris.miaskowski@nursing.ucsf.edu.
University of California, San Francisco · US

Funding

FATIGUE, PAIN, AND SLEEP PROBLEMS DURING RADIATIONR01NR004835 · NINR · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 1999 to 2002
$2.2M
Interdisciplinary Training of Nurse Scientists in Cancer Survivorship ResearchT32NR011972 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENDER, CATHERINE M. · 2010 to 2014
$1.3M
Advancing the Science of Symptom Management in Oncology PatientsK05CA168960 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2013 to 2017
$453k
Identification of Genetic Markers Associated With Attentional FatigueF31NR012604 · NINR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MERRIMAN, JOHN D. · 2010 to 2013
$95k
NCI NIH HHS CA168960NCI NIH HHS K05 CA168960NCRR NIH HHS KL2 RR624130NINR NIH HHS F31 NR012604NINR NIH HHS NR011972NINR NIH HHS NR012604NINR NIH HHS NR04835NINR NIH HHS R01 NR004835NINR NIH HHS T32 NR011972
6 · The paper itself

Abstract

purpose of the researchEvaluate for associations between variations in genes involved in catecholaminergic, gamma-aminobutyric acid (GABA)-ergic, and serotonergic mechanisms of neurotransmission and attentional function latent classes. PATIENTS AND

methodsThis descriptive, longitudinal study was conducted at two radiation therapy departments. The sample included three latent classes of individuals with distinct trajectories of self-reported attentional function during radiation therapy, who were previously identified using growth mixture modeling among 167 oncology patients and 85 of their family caregivers. Multivariable models were used to evaluate for genotypic associations of neurotransmission genes with attentional function latent class membership, after controlling for covariates.

resultsVariations in catecholaminergic (i.e., ADRA1D rs4815675, SLC6A3 rs37022), GABAergic (i.e., SLC6A1 rs2697138), and serotonergic (i.e., HTR2A rs2296972, rs9534496) neurotransmission genes were significant predictors of latent class membership in multivariable models.

conclusionsFindings suggest that variations in genes that encode for three distinct but related neurotransmission systems are involved in alterations in attentional function. Knowledge of both phenotypic and genetic markers associated with alterations in attentional function can be used by clinicians to identify patients and family caregivers who are at higher risk for this symptom. Increased understanding of the genetic markers associated with alterations in attentional function may provide insights into the underlying mechanisms for this significant clinical problem.

Indexed as

CaregiversAgedAttentionBreast NeoplasmsCaliforniaCatecholaminesCytokinesFamilyFemalegamma-Aminobutyric AcidGenotypeHumansLongitudinal StudiesMaleMiddle AgedPhenotypeCatecholaminesCytokinesgamma-Aminobutyric AcidSerotonin AgentsAttentional functionCancerCatecholaminesGamma-aminobutyric acidNeurotransmissionSerotonin

Identifiers

PMID25524657
PMCPMC4468043
OpenAlexW2039903259

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.