ArticleJournal of the American College of Cardiology2014
Engineered electrical conduction tract restores conduction in complete heart block: from in vitro to in vivo proof of concept.
Article in Journal of the American College of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Models of cardiomyocyte-non-myocyte electrical interactions.The Journal of physiology · 2026Review
- Nonmyocytes as electrophysiological contributors to cardiac excitation and conduction.American journal of physiology. Heart and circulatory physiology · 2023Review
- Influence of Diameter and Cyclic Mechanical Stimulation on the Beating Frequency of Myocardial Cell-Laden Fibers.Gels (Basel, Switzerland) · 2023Article
- The heterocellular heart: identities, interactions, and implications for cardiology.Basic research in cardiology · 2023Review
- Assessment of arrhythmia mechanism and burden of the infarcted ventricles following remuscularization with pluripotent stem cell-derived cardiomyocyte patches using patient-derived models.Cardiovascular research · 2022Article
- Prenatal ethanol exposure impairs the conduction delay at the atrioventricular junction in the looping heart.American journal of physiology. Heart and circulatory physiology · 2021Article
- Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review.Frontiers in physiology · 2021Review
- Engineered Cardiac Pacemaker Nodes Created by TBX18 Gene Transfer Overcome Source-Sink Mismatch.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Implantation of engineered conduction tissue in the rat heart.Molecular medicine reports · 2019Article
- Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation.Biomaterials · 2018Article
- Electrotonic coupling of excitable and nonexcitable cells in the heart revealed by optogenetics.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Probing the Electrophysiology of the Developing Heart.Journal of cardiovascular development and disease · 2016Review
- Fibroblast-myocyte coupling in the heart: Potential relevance for therapeutic interventions.Journal of molecular and cellular cardiology · 2016Review
- Reprogramming the conduction system: Onward toward a biological pacemaker.Trends in cardiovascular medicine · 2016Review
- Atrial Fibrillation and Fibrosis: Beyond the Cardiomyocyte Centric View.BioMed research international · 2015Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCardiac electrical conduction delays and blocks cause rhythm disturbances such as complete heart block, which can be fatal. Standard of care relies on electronic devices to artificially restore synchrony. We sought to create a new modality for treating these disorders by engineering electrical conduction tracts designed to propagate electrical impulses.
objectivesThis study sought to create a new approach for treating cardiac conduction disorders by using engineered electrical conduction tracts (EECTs).
methodsParamagnetic beads were conjugated with an antibody to gamma-sarcoglycan, a cardiomyocyte cell surface antigen, and mixed with freshly isolated neonatal rat ventricular cardiomyocytes. A magnetic field was used to pattern a linear EECT.
resultsIn an in vitro model of conduction block, the EECT was patterned so that it connected 2 independently beating neonatal rat ventricular cardiomyocyte monolayers; it achieved coordinated electrical activity, with action potentials propagating from 1 region to the other via EECT. Spiking the EECT with heart-derived stromal cells yielded stable structures with highly reproducible conduction velocities. Transplantation of EECTs in vivo restored atrioventricular conduction in a rat model of complete heart block.
conclusionsAn EECT can re-establish electrical conduction in the heart. This novel approach could, in principle, be used not only to treat cardiac arrhythmias but also to repair other organs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.