ReviewSeminars in fetal & neonatal medicine2015
Movement disorders due to bilirubin toxicity.
Review in Seminars in fetal & neonatal medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- Stannsoporfin with phototherapy to treat hyperbilirubinemia in newborn hemolytic disease.Journal of perinatology : official journal of the California Perinatal Association · 2022Trial
- Article
- Article
- Associations of risk factors and the number of risk factors with the classification, GMFCS level and comorbidities with cerebral palsy: a retrospective study.BMC pediatrics · 2024Article
- Selective Vulnerability of GABAergic Inhibitory Interneurons to Bilirubin Neurotoxicity in the Neonatal Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Maternal linoleic acid-rich diet ameliorates bilirubin neurotoxicity in offspring mice.Cell death discovery · 2024Article
- Bilirubin Exerts Protective Effects on Alveolar Type II Pneumocytes in an In Vitro Model of Oxidative Stress.International journal of molecular sciences · 2024Article
- Developmental outcome of neonates underwent exchange transfusion due to hyperbilirubinemia: A single-center experience.Journal of education and health promotion · 2024Article
- Bilirubin and Redox Stress in Age-Related Brain Diseases.Antioxidants (Basel, Switzerland) · 2023Review
- Inflammation, Dopaminergic Brain and Bilirubin.International journal of molecular sciences · 2023Review
- The added value of brain MR spectroscopy in children with Crigler-Najjar syndrome type-I: correlation with demographic, neurodevelopmental, and laboratory findings.The British journal of radiology · 2023Article
- A zebrafish model for studying the mechanisms of newborn hyperbilirubinemia and bilirubin-induced neurological damage.Frontiers in cell and developmental biology · 2023Article
- Bile pigments in emergency and critical care medicine.European journal of medical research · 2022Review
- Clinical Assessment of Neuroinflammatory Markers and Antioxidants in Neonates with Hyperbilirubinemia and Their Association with Acute Bilirubin Encephalopathy.Children (Basel, Switzerland) · 2022Article
- Prediction of Significant Hyperbilirubinemia in Peruvian Term Newborns.Global pediatric health · 2022Article
- Complex dystonias: an update on diagnosis and care.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- [Role of pyroptosis in bilirubin-induced microglial injury].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Review of Hereditary and Acquired Rare Choreas.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Review
- The effects of hyperbilirubinaemia on synaptic plasticity in the dentate gyrus region of the rat hippocampusArchives of medical science : AMS · 2020Article
- Bilirubin Induced Encephalopathy.Iranian journal of child neurology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Advances in the care of neonatal hyperbilirubinemia have led to a decreased incidence of kernicterus. However, neonatal exposure to high levels of bilirubin continues to cause severe motor symptoms and cerebral palsy (CP). Exposure to moderate levels of unconjugated bilirubin may also cause damage to the developing central nervous system, specifically the basal ganglia and cerebellum. Brain lesions identified using magnetic resonance imaging following extreme hyperbilirubinemia have been linked to dyskinetic CP. Newer imaging techniques, such as diffusion tensor imaging or single-photon emission computed tomography, allow quantification of more subtle white matter injury following presumed exposure to unbound bilirubin, and may explain more subtle movement disorders. New categories of bilirubin-induced neurologic dysfunction, characterized by subtle bilirubin encephalopathy following moderate hyperbilirubinemia, have been implicated in long-term motor function. Further research is needed to identify subtle impairments resulting from moderate-severe neonatal hyperbilirubinemia, to understand the influence of perinatal risk factors on bilirubin toxicity, and to develop neuroprotective treatment strategies to prevent movement disorders due to bilirubin toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.