ArticlePhysiological reports2014
A method for longitudinal, transcranial imaging of blood flow and remodeling of the cerebral vasculature in postnatal mice.
Article in Physiological reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Experimental and theoretical model of microvascular network remodeling and blood flow redistribution following minimally invasive microvessel laser ablation.Scientific reports · 2024Article
- Time-Lapse Observation of Cell Dynamics During Angiogenesis Using the Rat Mesentery Culture Model.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Arousal state transitions occlude sensory-evoked neurovascular coupling in neonatal mice.Communications biology · 2023Article
- Deep Imaging to Dissect Microvascular Contributions to White Matter Degeneration in Rodent Models of Dementia.Stroke · 2023Review
- Image-based angio-adaptation modelling: a playground to study cerebrovascular development.Frontiers in physiology · 2023Article
- Reinforced thinned-skull window for repeated imaging of the neonatal mouse brain.Neurophotonics · 2022Article
- Imaging the construction of capillary networks in the neonatal mouse brain.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- In vivo imaging of hemodynamic redistribution and arteriogenesis across microvascular network.Microcirculation (New York, N.Y. : 1994) · 2020Article
- Postnatal development of cerebrovascular structure and the neurogliovascular unit.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- Structural and Functional Features of Developing Brain Capillaries, and Their Alteration in Schizophrenia.Frontiers in cellular neuroscience · 2020Review
- Twitches, Blinks, and Fidgets: Important Generators of Ongoing Neural Activity.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2019Review
- Preclinical Imaging Biomarkers for Postischaemic Neurovascular Remodelling.Contrast media & molecular imaging · 2019Review
- The pial vasculature of the mouse develops according to a sensory-independent program.Scientific reports · 2018Article
- Double-pulse laser illumination method for measuring fast cerebral blood flow velocities in the deep brain using a fiber-bundle-based endomicroscopy system.Biomedical optics express · 2018Article
- Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal.NeuroImage · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
In the weeks following birth, both the brain and the vascular network that supplies it undergo dramatic alteration. While studies of the postnatal evolution of the pial vasculature and blood flow through its vessels have been previously done histologically or acutely, here we describe a neonatal reinforced thin-skull preparation for longitudinally imaging the development of the pial vasculature in mice using two-photon laser scanning microscopy. Starting with mice as young as postnatal day 2 (P2), we are able to chronically image cortical areas >1 mm(2), repeatedly for several consecutive days, allowing us to observe the remodeling of the pial arterial and venous networks. We used this method to measure blood velocity in individual vessels over multiple days, and show that blood flow through individual pial venules was correlated with subsequent diameter changes. This preparation allows the longitudinal imaging of the developing mammalian cerebral vascular network and its physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.