Evidence map›Paper›PMID 2552408›Full record

ArticleNucleic acids research1989

Transcriptional trans-repression by the c-myb proto-oncogene product.

H Nakagoshi, T Nagase, Y Ueno, S Ishii

Open access · greenAbstract read
In one paragraph

Article in Nucleic acids research, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Transformation by v-Myb.Oncogene · 1999
    Review
  7. Article
  8. Recognition of specific DNA sequences by the c-myb protooncogene product: role of three repeat units in the DNA-binding domain.Proceedings of the National Academy of Sciences of the United States of America · 1993
    Article
  9. Article
  10. Article
  11. The PR264/c-myb connection: expression of a splicing factor modulated by a nuclear protooncogene.Proceedings of the National Academy of Sciences of the United States of America · 1992
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

H NakagoshiLaboratory of Molecular Genetics, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan.
T Nagase
Y Ueno
S Ishii
Laboratory of Molecular Genetics · PLTokyo University of Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report that the c-myb protein binds to another site, MBS-II, in the SV40 enhancer with low affinity. In co-transfection experiments with a c-myb expression plasmid, tandem repeats of the sequence containing the MBS-II site induced c-myb-dependent transcriptional repression. Results of mutational analyses of the sequence around the MBS-II site suggested that the c-myb protein represses transcription by competing with another trans-activator. These results indicate that c-myb protein can regulate transcription not only positively but also negatively.

Indexed as

Gene Expression Regulation, ViralRegulatory Sequences, Nucleic AcidChromosome MappingDeoxyribonuclease IDNA-Binding ProteinsDNA Mutational AnalysisEnhancer Elements, GeneticIn Vitro TechniquesPlasmidsProto-Oncogene ProteinsProto-Oncogene Proteins c-mybRepressor ProteinsSimian virus 40Transcription FactorsTranscription, GeneticDeoxyribonuclease IDNA-Binding ProteinsProto-Oncogene ProteinsProto-Oncogene Proteins c-mybRepressor ProteinsTranscription Factors

Identifiers

PMID2552408
PMCPMC334811
OpenAlexW2116500121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.