Evidence map›Paper›PMID 25523964›Full record

ArticleParkinsonism & related disorders2015

Medication non-adherence in essential tremor.

Elan D Louis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Medication Adherence in Chinese Patients with Essential Tremor: A Real World Study.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025
    Article
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Emerging strategies in the management of essential tremor.Therapeutic advances in neurological disorders · 2017
    Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Elan D LouisGH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address: EDL2@columbia.edu.

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Clinical Pathological Study of Cognitive Impairment in Essential TremorR01NS086736 · NINDS · YALE UNIVERSITY · PI COSENTINO, STEPHANIE ANN, LOUIS, ELAN D · 2014 to 2023
$8.1M
ENVIRONMENTAL EPIDEMIOLOGY OF ESSENTIAL TREMORR01NS039422 · NINDS · YALE UNIVERSITY · PI LOUIS, ELAN D · 2000 to 2013
$7.7M
Identification of Susceptibility Genes for Essential TremorR01NS073872 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLARK, LORRAINE N, LOUIS, ELAN D · 2011 to 2019
$7.4M
GENETIC EPIDEMIOLOGY OF PARKINSONS DISEASER01NS036630 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARDER, KAREN S · 1998 to 2008
$6.8M
NEUROEPIDEMIOLOGY TRAINING PROGRAMT32NS007153 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GU, YIAN, WILLEY, JOSHUA ZEBADIAH · 1987 to 2023
$6.2M
Pathogenesis Of Essential Tremor: Cerebellar MetabolismR01NS042859 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOUIS, ELAN D · 2003 to 2012
$4.9M
in Vivo Quantification of Cerebellar GABA and NAA in Essential TremorR01NS085136 · NINDS · YALE UNIVERSITY · PI MATUSKEY, DAVID A · 2013 to 2017
$3.3M
Essential Tremor: Gene expression profiling in cerebellar Purkinje cellsR21NS077094 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FAUST, PHYLLIS L · 2011 to 2012
$440k
NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30 ES09089NINDS NIH HHS R01 NS036630NINDS NIH HHS R01 NS039422NINDS NIH HHS R01 NS042859NINDS NIH HHS R01 NS073872NINDS NIH HHS R01 NS085136NINDS NIH HHS R01 NS086736NINDS NIH HHS R01 NS36630NINDS NIH HHS R01 NS39422NINDS NIH HHS R21 NS077094NINDS NIH HHS T32 NS007153NINDS NIH HHS T32 NS07153-24
6 · The paper itself

Abstract

backgroundThere are numerous studies of medication adherence in a variety of chronic diseases including Parkinson's disease; however, there are no such studies in patients with essential tremor (ET). This study aimed to (1) present self-report data on medication adherence in ET cases, (2) examine the demographic and clinical factors that might be associated with lower medication adherence.

methods151 ET cases were enrolled in a clinical-epidemiological study at Columbia University. An 11-item medication adherence questionnaire, modeled after the Morisky medication adherence questionnaire, was administered.

resultsSeventy-three (48.3%) of 151 cases were taking daily medication for ET. One-third (24/73; 32.9%) of cases reported that they sometimes forgot to take their medication, and 1 in 5 (15/73; 20.5%) reported missed doses within the past week. Most striking was that nearly 1 in 4 (17/73; 23.3%) reported that there were whole days in the past two weeks in which they had not taken their medication. A factor analysis revealed four factors that captured different aspects of non-adherence. Higher non-adherence was associated with more depressive symptoms, younger age, and less severe tremor but was not associated with type or number of ET medications.

conclusionsApproximately one in four ET patients reported whole days in the past two weeks in which they had not taken their medication. It is possible that this relatively high rate of non-adherence could be a function of the poor therapeutic efficacy of the medications currently available to treat ET.

Indexed as

Medication AdherenceAgedAged, 80 and overEssential TremorFemaleFollow-Up StudiesHumansMaleMiddle AgedSurveys and QuestionnairesAdherenceClinicalComplianceEpidemiologyEssential tremorTreatment

Identifiers

PMID25523964
PMCPMC4306620

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.