ArticleGenome biology and evolution2014
Genome-wide patterns of genetic polymorphism and signatures of selection in Plasmodium vivax.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- New Evidence of TLR4 and TLR9 Variants Influencing Parasitaemia and Symptoms of Plasmodium vivax Infection.International journal of immunogenetics · 2025Article
- Patterns of Change in Nucleotide Diversity Over Gene Length.Genome biology and evolution · 2024Article
- Population genomic evidence of structured and connectedEcology and evolution · 2024Article
- Comparative transcriptomics reveal differential gene expression among Plasmodium vivax geographical isolates and implications on erythrocyte invasion mechanisms.PLoS neglected tropical diseases · 2024Article
- Reduced polymorphism of Plasmodium vivax early transcribed membrane protein (PvETRAMP) 11.2.Parasites & vectors · 2023Review
- Vivax malaria: a possible stumbling block for malaria elimination in India.Frontiers in public health · 2023Review
- Whole Genome Sequencing Contributions and Challenges in Disease Reduction Focused on Malaria.Biology · 2022Review
- GIP: an open-source computational pipeline for mapping genomic instability from protists to cancer cells.Nucleic acids research · 2022Article
- Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes.PLoS neglected tropical diseases · 2020Article
- Article
- Malaria Molecular Epidemiology: An Evolutionary Genetics Perspective.Microbiology spectrum · 2019Review
- Tail Wags the Dog? Functional Gene Classes Driving Genome-Wide GC Content in Plasmodium spp.Genome biology and evolution · 2019Article
- Article
- Identifying PotentialFrontiers in genetics · 2018Article
- Review
- Genome-wide scans for the identification of Plasmodium vivax genes under positive selection.Malaria journal · 2017Article
- Evolution of the merozoite surface protein 7 (msp7) family in Plasmodium vivax and P. falciparum: A comparative approach.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2017Article
- PvGAMA reticulocyte binding activity: predicting conserved functional regions by natural selection analysis.Parasites & vectors · 2017Article
- Identification of a novel merozoite surface antigen of Plasmodium vivax, PvMSA180.Malaria journal · 2017Article
- Whole-genome sequencing of a Plasmodium vivax clinical isolate exhibits geographical characteristics and high genetic variation in China-Myanmar border area.BMC genomics · 2017Article
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3 authors.
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Abstract
Plasmodium vivax is the most prevalent human malaria parasite outside of Africa. Yet, studies aimed to identify genes with signatures consistent with natural selection are rare. Here, we present a comparative analysis of the pattern of genetic variation of five sequenced isolates of P. vivax and its divergence with two closely related species, Plasmodium cynomolgi and Plasmodium knowlesi, using a set of orthologous genes. In contrast to Plasmodium falciparum, the parasite that causes the most lethal form of human malaria, we did not find significant constraints on the evolution of synonymous sites genome wide in P. vivax. The comparative analysis of polymorphism and divergence across loci allowed us to identify 87 genes with patterns consistent with positive selection, including genes involved in the "exportome" of P. vivax, which are potentially involved in evasion of the host immune system. Nevertheless, we have found a pattern of polymorphism genome wide that is consistent with a significant amount of constraint on the replacement changes and prevalent negative selection. Our analyses also show that silent polymorphism tends to be larger toward the ends of the chromosomes, where many genes involved in antigenicity are located, suggesting that natural selection acts not only by shaping the patterns of variation within the genes but it also affects genome organization.
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