ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
Perinatal vs genetic programming of serotonin states associated with anxiety.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Safety in treatment: Classical pharmacotherapeutics and new avenues for addressing maternal depression and anxiety during pregnancy.Pharmacological reviews · 2025Review
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- Optogenetic Stimulation of Midbrain Dopamine Neurons Produces Striatal Serotonin Release.ACS chemical neuroscience · 2022Article
- Implantable aptamer-field-effect transistor neuroprobes for in vivo neurotransmitter monitoring.Science advances · 2021Article
- Simultaneous serotonin and dopamine monitoring across timescales by rapid pulse voltammetry with partial least squares regression.Analytical and bioanalytical chemistry · 2021Article
- Serotonin-related rodent models of early-life exposure relevant for neurodevelopmental vulnerability to psychiatric disorders.Translational psychiatry · 2021Review
- The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice.Scientific reports · 2021Article
- Reduced Motivation in Perinatal Fluoxetine-Treated Mice: A Hypodopaminergic Phenotype.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link.International journal of molecular sciences · 2020Review
- Perinatal fluoxetine exposure disrupts the circadian response to a phase-shifting challenge in female rats.Psychopharmacology · 2020Article
- Article
- Aptamer-field-effect transistors overcome Debye length limitations for small-molecule sensing.Science (New York, N.Y.) · 2018Article
- Bad Behavior: Improving Reproducibility in Behavior Testing.ACS chemical neuroscience · 2018Article
- Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice.Acta pharmacologica Sinica · 2018Article
- Developmental changes in serotonin signaling: Implications for early brain function, behavior and adaptation.Neuroscience · 2017Review
- Article
- Integrins in synapse regulation.Nature reviews. Neuroscience · 2016Review
- Sex differences, learning flexibility, and striatal dopamine D1 and D2 following adolescent drug exposure in rats.Behavioural brain research · 2016Article
- Maternal Pharmacokinetics and Fetal Disposition of (±)-Citalopram during Mouse Pregnancy.ACS chemical neuroscience · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Large numbers of women undergo antidepressant treatment during pregnancy; however, long-term consequences for their offspring remain largely unknown. Rodents exposed to serotonin transporter (SERT)-inhibiting antidepressants during development show changes in adult emotion-like behavior. These changes have been equated with behavioral alterations arising from genetic reductions in SERT. Both models are highly relevant to humans yet they vary in their time frames of SERT disruption. We find that anxiety-related behavior and, importantly, underlying serotonin neurotransmission diverge between the two models. In mice, constitutive loss of SERT causes life-long increases in anxiety-related behavior and hyperserotonemia. Conversely, early exposure to the antidepressant escitalopram (ESC; Lexapro) results in decreased anxiety-related behavior beginning in adolescence, which is associated with adult serotonin system hypofunction in the ventral hippocampus. Adult behavioral changes resulting from early fluoxetine (Prozac) exposure were different from those of ESC and, although somewhat similar to SERT deficiency, were not associated with changes in hippocampal serotonin transmission in late adulthood. These findings reveal dissimilarities in adult behavior and neurotransmission arising from developmental exposure to different widely prescribed antidepressants that are not recapitulated by genetic SERT insufficiency. Moreover, they support a pivotal role for serotonergic modulation of anxiety-related behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.