ArticleJournal of the American Chemical Society2015
Single (19)F probe for simultaneous detection of multiple metal ions using miCEST MRI.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 76 citations in OpenAlex.
- Molecular Imaging of In Vivo Zinc Distribution Using Nuclear and Magnetic Resonance Imaging.Chemical & biomedical imaging · 2026Review
- Recent Advances in Fluorinated Colloidal Nanosystems for Biological Detection and Surface Coating.Polymers · 2026Review
- Design Chemical Exchange Saturation Transfer Contrast Agents and Nanocarriers for Imaging Proton ExchangeACS nano · 2024Review
- The role of responsive MRI probes in the past and the future of molecular imaging.Chemical science · 2024Review
- A Reactive and Specific Sensor for Activity-BasedACS sensors · 2024Article
- Radiofrequency labeling strategies in chemical exchange saturation transfer MRI.NMR in biomedicine · 2023Review
- Design Principles of Responsive RelaxometricInorganic chemistry · 2022Article
- Fast Ion-Chelate Dissociation Rate forJournal of the American Chemical Society · 2021Article
- Versatile non-luminescent color palette based on guest exchange dynamics in paramagnetic cavitands.Nature communications · 2021Article
- Enhanced CaScientific reports · 2021Article
- Review
- Elucidating dissociation activation energies in host-guest assemblies featuring fast exchange dynamics.Chemical science · 2020Article
- From Zn(II) to Cu(II) Detection by MRI Using Metal-Based Probes: Current Progress and Challenges.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Development of Zinc-Specific iCEST MRI as an Imaging Biomarker for Prostate Cancer.Angewandte Chemie (International ed. in English) · 2019Article
- Fluorine polymer probes for magnetic resonance imaging: quo vadis?Magma (New York, N.Y.) · 2019Review
- Perfluorocarbon-BasedAngewandte Chemie (International ed. in English) · 2018Article
- Probing the brain with molecular fMRI.Current opinion in neurobiology · 2018Review
- Local Intratracheal Delivery of Perfluorocarbon Nanoparticles to Lung Cancer Demonstrated with Magnetic Resonance Multimodal Imaging.Theranostics · 2018Article
- Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors.ACS central science · 2017Article
- Advances in Monitoring Cell-Based Therapies with Magnetic Resonance Imaging: Future Perspectives.International journal of molecular sciences · 2017Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The local presence and concentration of metal ions in biological systems has been extensively studied ex vivo using fluorescent dyes. However, the detection of multiple metal ions in vivo remains a major challenge. We present a magnetic resonance imaging (MRI)-based method for noninvasive detection of specific ions that may be coexisting, using the tetrafluorinated derivative of the BAPTA (TF-BAPTA) chelate as a (19)F chelate analogue of existing optical dyes. Taking advantage of the difference in the ion-specific (19)F nuclear magnetic resonance (NMR) chemical shift offset (Δω) values between the ion-bound and free TF-BAPTA, we exploited the dynamic exchange between ion-bound and free TF-BAPTA to obtain MRI contrast with multi-ion chemical exchange saturation transfer (miCEST). We demonstrate that TF-BAPTA as a prototype single (19)F probe can be used to separately visualize mixed Zn(2+) and Fe(2+) ions in a specific and simultaneous fashion, without interference from potential competitive ions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.