ArticleNeurobiology of aging2015
Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study.
Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Imaging tau burden in dementia with Lewy bodies using [Neurobiology of aging · 2021Article
- Genetic regulation and heritability of miRNA and mRNA expression link to phosphorus utilization and gut microbiome.Open biology · 2021Article
- Measuring cerebral perfusion with [Brain communications · 2021Article
- Neuroimaging endophenotypes of type 2 diabetes mellitus: a discordant sibling pair study.Quantitative imaging in medicine and surgery · 2019Article
- Cerebral Blood Flow in Community-Based Older Twins Is Moderately Heritable: An Arterial Spin Labeling Perfusion Imaging Study.Frontiers in aging neuroscience · 2019Article
- Genome-wide association study reveals genetic loci and candidate genes for average daily gain in Duroc pigs.Asian-Australasian journal of animal sciences · 2018Article
- The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals.Genome biology and evolution · 2017Article
- Heritability of white matter microstructure in late middle age: A twin study of tract-based fractional anisotropy and absolute diffusivity indices.Human brain mapping · 2017Article
- Model based heritability scores for high-throughput sequencing data.BMC bioinformatics · 2017Article
- Analysis of the relationships between type 2 diabetes status, glycemic control, and neuroimaging measures in the Diabetes Heart Study Mind.Acta diabetologica · 2016Article
- Dopamine pathway gene variants may modulate cognitive performance in the DHS - Mind Study.Brain and behavior · 2016Article
- Analysis of advanced glycation end products in the DHS Mind Study.Journal of diabetes and its complications · 2016Article
- Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes.Journal of diabetes and its complicationsArticle
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Authors and funding
9 authors.
Funding
Abstract
Patients with type 2 diabetes are at increased risk of age-related cognitive decline and dementia. Neuroimaging measures such as white matter lesion volume, brain volume, and fractional anisotropy may reflect the pathogenesis of these cognitive declines, and genetic factors may contribute to variability in these measures. This study examined multiple neuroimaging measures in 465 participants from 238 families with extensive genotype data in the type 2 diabetes enriched Diabetes Heart Study-Mind cohort. Heritability of these phenotypes and their association with candidate single-nucleotide polymorphisms (SNPs), and SNP data from genome- and exome-wide arrays were explored. All neuroimaging measures analyzed were significantly heritable (ĥ(2) = 0.55-0.99 in unadjusted models). Seventeen candidate SNPs (from 16 genes/regions) associated with neuroimaging phenotypes in prior studies showed no significant evidence of association. A missense variant (rs150706952, A432V) in PLEKHG4B from the exome-wide array was significantly associated with white matter mean diffusivity (p = 3.66 × 10(-7)) and gray matter mean diffusivity (p = 2.14 × 10(-7)). This analysis suggests genetic factors contribute to variation in neuroimaging measures in a population enriched for metabolic disease and other associated comorbidities.
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