Evidence map›Paper›PMID 25523590›Full record

ArticleAJNR. American journal of neuroradiology2015

Cerebral microbleeds: different prevalence, topography, and risk factors depending on dementia diagnosis—the Karolinska Imaging Dementia Study.

S Shams, J Martola, T Granberg, X Li, M Shams, S M Fereshtehnejad, L Cavallin, P Aspelin, M Kristoffersen-Wiberg, L O Wahlund

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Cerebral amyloid angiopathy: a narrative review.Frontiers in aging neuroscience · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Vascular contributions to Alzheimer's disease.Translational research : the journal of laboratory and clinical medicine · 2023
    Review
  17. Review
  18. Article
  19. Article
  20. Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

S ShamsClinical Science, Intervention, and Technology (S.S., J.M., T.G., M.S., L.C., P.A., M.K.-W.), Division of Medical Imaging and Technology, Karolinska Institute, Stockholm, Sweden Department of Radiology (S.S., J.M., T.G., M.S., L.C., P.A., M.K.-W.) sara.shams@ki.se.
J MartolaClinical Science, Intervention, and Technology (S.S., J.M., T.G., M.S., L.C., P.A., M.K.-W.), Division of Medical Imaging and Technology, Karolinska Institute, Stockholm, Sweden Department of Radiology (S.S., J.M., T.G., M.S., L.C., P.A., M.K.-W.).
T GranbergClinical Science, Intervention, and Technology (S.S., J.M., T.G., M.S., L.C., P.A., M.K.-W.), Division of Medical Imaging and Technology, Karolinska Institute, Stockholm, Sweden Department of Radiology (S.S., J.M., T.G., M.S., L.C., P.A., M.K.-W.).
X LiFrom the Departments of Neurobiology, Care Sciences, and Society (X.L., S.M.F., L.O.W.) Division of Clinical Geriatrics (X.L., S.M.F., L.O.W.), Karolinska University Hospital, Stockholm, Sweden.
M ShamsClinical Science, Intervention, and Technology (S.S., J.M., T.G., M.S., L.C., P.A., M.K.-W.), Division of Medical Imaging and Technology, Karolinska Institute, Stockholm, Sweden Department of Radiology (S.S., J.M., T.G., M.S., L.C., P.A., M.K.-W.).
S M FereshtehnejadFrom the Departments of Neurobiology, Care Sciences, and Society (X.L., S.M.F., L.O.W.) Division of Clinical Geriatrics (X.L., S.M.F., L.O.W.), Karolinska University Hospital, Stockholm, Sweden.
L CavallinClinical Science, Intervention, and Technology (S.S., J.M., T.G., M.S., L.C., P.A., M.K.-W.), Division of Medical Imaging and Technology, Karolinska Institute, Stockholm, Sweden Department of Radiology (S.S., J.M., T.G., M.S., L.C., P.A., M.K.-W.).
P AspelinClinical Science, Intervention, and Technology (S.S., J.M., T.G., M.S., L.C., P.A., M.K.-W.), Division of Medical Imaging and Technology, Karolinska Institute, Stockholm, Sweden Department of Radiology (S.S., J.M., T.G., M.S., L.C., P.A., M.K.-W.).
M Kristoffersen-WibergClinical Science, Intervention, and Technology (S.S., J.M., T.G., M.S., L.C., P.A., M.K.-W.), Division of Medical Imaging and Technology, Karolinska Institute, Stockholm, Sweden Department of Radiology (S.S., J.M., T.G., M.S., L.C., P.A., M.K.-W.).
L O WahlundFrom the Departments of Neurobiology, Care Sciences, and Society (X.L., S.M.F., L.O.W.) Division of Clinical Geriatrics (X.L., S.M.F., L.O.W.), Karolinska University Hospital, Stockholm, Sweden.
Karolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeCerebral microbleeds are thought to represent cerebral amyloid angiopathy when in lobar regions of the brain and hypertensive arteriopathy when in deep and infratentorial locations. By studying cerebral microbleeds, their topography, and risk factors, we aimed to gain an insight into the vascular and amyloid pathology of dementia diagnoses and increase the understanding of cerebral microbleeds in dementia. MATERIALS AND

methodsWe analyzed 1504 patients (53% women; mean age, 63 ± 10 years; 10 different dementia diagnoses) in this study. All patients underwent MR imaging as part of the dementia investigation, and all their clinical parameters were recorded.

resultsAmong the 1504 patients with dementia, 22% had cerebral microbleeds. Cerebral microbleed topography was predominantly lobar (P = .01) and occipital (P = .007) in Alzheimer disease. Patients with cerebral microbleeds were significantly older (P < .001), were more frequently male (P < .001), had lower cognitive scores (P = .006), and more often had hypertension (P < .001). Risk factors for cerebral microbleeds varied depending on the dementia diagnosis. Odds ratios for having cerebral microbleeds increased with the number of risk factors (hypertension, hyperlipidemia, diabetes, male sex, and age 65 and older) in the whole patient group and increased differently in the separate dementia diagnoses.

conclusionsPrevalence, topography, and risk factors of cerebral microbleeds vary depending on the dementia diagnosis and reflect the inherent pathology of different dementia diagnoses. Because cerebral microbleeds are seen as possible predictors of intracerebral hemorrhage, their increasing prevalence with an increasing number of risk factors, as shown in our study, may require taking the number of risk factors into account when deciding on anticoagulant therapy in dementia.

Indexed as

AgedAged, 80 and overBrainCerebral HemorrhageDementiaFemaleHumansMagnetic Resonance ImagingMalePrevalenceRisk Factors

Identifiers

PMID25523590
PMCPMC7964321
OpenAlexW2130583999

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.