ArticleNature communications2014
Decelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 153 citations in OpenAlex.
- The highly heterozygous European amphioxus (Branchiostoma lanceolatum) at the edge of panmixia.PLoS genetics · 2026Article
- Insights into cephalochordate genome and gene evolution from the early-diverging amphioxusProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Evolutionary dynamics of sex determination in Branchiostoma belcheri driven by repeated transposition of a single novel gene.Nature communications · 2026Article
- Direct detection of meiotic recombination events in the highly heterozygous amphioxus genome.Advanced biotechnology · 2025Article
- Apaf-1 is an evolutionarily conserved DNA sensor that switches the cell fate between apoptosis and inflammation.Cell discovery · 2025Article
- The evolution of tenascins.BMC ecology and evolution · 2024Article
- FishTEDB 2.0: an update fish transposable element (TE) database with new functions to facilitate TE research.Database : the journal of biological databases and curation · 2024Article
- The IL-17 pathway intertwines with neurotrophin and TLR/IL-1R pathways since its domain shuffling origin.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences.Nature ecology & evolution · 2024Article
- Genome-Wide Comparative Analysis of SRCR Gene Superfamily in Invertebrates Reveals Massive and Independent Gene Expansions in the Sponge and Sea Urchin.International journal of molecular sciences · 2024Article
- Ancient fish lineages illuminate toll-like receptor diversification in early vertebrate evolution.Immunogenetics · 2023Article
- Article
- Amphioxus adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U and A-to-I deamination of DNA.Communications biology · 2023Article
- Three amphioxus reference genomes reveal gene and chromosome evolution of chordates.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Parallel evolution of amphioxus and vertebrate small-scale gene duplications.Genome biology · 2022Article
- Encyclopaedia of eukaryotic DNA methylation: from patterns to mechanisms and functions.Biochemical Society transactions · 2022Article
- Deep whole-genome resequencing sheds light on the distribution and effect of amphioxus SNPs.BMC genomic data · 2022Article
- Two novel mollusk short-form ApeC-containing proteins act as pattern recognition proteins for peptidoglycan.Frontiers in immunology · 2022Article
- 'Cannibalism' of exogenous DNA sequences: The ancestral form of adaptive immunity which entails recognition of danger.Frontiers in immunology · 2022Review
- Ciliary photoreceptors in sea urchin larvae indicate pan-deuterostome cell type conservation.BMC biology · 2021Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertebrates diverged from other chordates ~500 Myr ago and experienced successful innovations and adaptations, but the genomic basis underlying vertebrate origins are not fully understood. Here we suggest, through comparison with multiple lancelet (amphioxus) genomes, that ancient vertebrates experienced high rates of protein evolution, genome rearrangement and domain shuffling and that these rates greatly slowed down after the divergence of jawed and jawless vertebrates. Compared with lancelets, modern vertebrates retain, at least relatively, less protein diversity, fewer nucleotide polymorphisms, domain combinations and conserved non-coding elements (CNE). Modern vertebrates also lost substantial transposable element (TE) diversity, whereas lancelets preserve high TE diversity that includes even the long-sought RAG transposon. Lancelets also exhibit rapid gene turnover, pervasive transcription, fastest exon shuffling in metazoans and substantial TE methylation not observed in other invertebrates. These new lancelet genome sequences provide new insights into the chordate ancestral state and the vertebrate evolution.
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