ArticleAmerican journal of hypertension2015
Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia.
Article in American journal of hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- A novel two-sample Mendelian randomization framework integrating common and rare variants: application to assess the effect of HDL-C on preeclampsia risk.Briefings in bioinformatics · 2026Article
- Genome-wide polygenic risk scores for hypertensive disease during pregnancy can also predict the risk for long-term cardiovascular disease.American journal of obstetrics and gynecology · 2023Article
- Article
- Pre-pregnancy blood pressure and pregnancy outcomes: a nationwide population-based study.BMC pregnancy and childbirth · 2022Article
- Prediction of Differentially Expressed Genes and a Diagnostic Signature of Preeclampsia via Integrated Bioinformatics Analysis.Disease markers · 2022Article
- Risk of pre-eclampsia in patients with a maternal genetic predisposition to common medical conditions: a case-control study.BJOG : an international journal of obstetrics and gynaecology · 2021Article
- Gene-Centric Analysis of Preeclampsia Identifies Maternal Association atHypertension (Dallas, Tex. : 1979) · 2018Article
- Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia.Hypertension in pregnancy · 2017Article
- Interactive effects of C-reactive protein levels on the association between APOE variants and triglyceride levels in a Taiwanese population.Lipids in health and disease · 2016Article
- Genetic Risk Score for Essential Hypertension and Risk of Preeclampsia.American journal of hypertension · 2016Article
- Precision test for precision medicine: opportunities, challenges and perspectives regarding pre-eclampsia as an intervention window for future cardiovascular disease.American journal of translational research · 2016Review
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundLarge epidemiologic studies support the role of dyslipidemia in preeclampsia; however, the etiology of preeclampsia or whether dyslipidemia plays a causal role remains unclear. We examined the association between the genetic predisposition to dyslipidemia and risk of preeclampsia using validated genetic markers of dyslipidemia.
methodsPreeclampsia cases (n = 164) and normotensive controls (n = 110) were selected from live birth certificates to nulliparous Iowa women during the period August 2002 to May 2005. Disease status was verified by medical chart review. Genetic predisposition to dyslipidemia was estimated by 4 genetic risk scores (GRS) (total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), and triglycerides) on the basis of established loci for blood lipids. Logistic regression analyses were used to evaluate the relationships between each of the 4 genotype scores and preeclampsia. Replication analyses were performed in an independent, US population of preeclampsia cases (n = 516) and controls (n = 1,097) of European ancestry.
resultsThe GRS related to higher levels of TC, LDL-C, and triglycerides demonstrated no association with the risk of preeclampsia in either the Iowa or replication population. The GRS related to lower HDL-C was marginally associated with an increased risk for preeclampsia (odds ratio (OR) = 1.03, 95% confidence interval (CI) = 0.99-1.07; P = 0.10). In the independent replication population, the association with the HDL-C GRS was also marginally significant (OR = 1.03, 95% CI: 1.00-1.06; P = 0.04).
conclusionsOur data suggest a potential effect between the genetic predisposition to dyslipidemic levels of HDL-C and an increased risk of preeclampsia, and, as such, suggest that dyslipidemia may be a component along the causal pathway to preeclampsia.
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