ArticleDiagnostic pathology2014
Breast cancer stromal elastosis is associated with mammography screening detection, low Ki67 expression and favourable prognosis in a population-based study.
Article in Diagnostic pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 31 citations in OpenAlex.
- The Association of Interstitial Fibrosis and Ki67 Marker Expression in Papillary Thyroid Carcinoma with Histopathological Findings and Prognosis of Total Thyroidectomy.Journal of clinical medicine · 2026Article
- Complex Features of Tumor-Infiltrating Lymphocytes (TILs) and Stromal Response After Neoadjuvant Breast Chemotherapy.Maedica · 2026Article
- Assessment of Stromal Elastin Fibers in Breast Cancer and Fibroadenomas: Is There a Correlation With Ultrasound Elastography Findings?European journal of breast health · 2022Article
- Interrelationships between the extracellular matrix and the immune microenvironment that govern epithelial tumour progression.Clinical science (London, England : 1979) · 2022Review
- Elastin in pulmonary pathology: relevance in tumours with a lepidic or papillary appearance. A comprehensive understanding from a morphological viewpoint.Histopathology · 2022Review
- Tumor-associated lymphocytes and macrophages are related to stromal elastosis and vascular invasion in breast cancer.The journal of pathology. Clinical research · 2021Article
- Elastosis in Breast Cancer as a Surrogate Marker for Estrogen Receptor Positivity.Oman medical journal · 2021Article
- Elastosis in ERα-positive male breast cancer.Virchows Archiv : an international journal of pathology · 2021Article
- Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer.PloS one · 2021Article
- Higher Ki67 expression in fibroblast like cells at invasive front indicates better clinical outcomes in oral squamous cell carcinoma patients.Bioscience reports · 2018Article
- Elastin molecular aging promotes MDA-MB-231 breast cancer cell invasiveness.FEBS open bio · 2018Article
- The clinicopathological significance of Ki67 in papillary thyroid carcinoma: a suitable indicator?World journal of surgical oncology · 2018Article
- Extra-nodal extension is a significant prognostic factor in lymph node positive breast cancer.PloS one · 2017Article
- Evaluation of Tumor Cell Proliferation by Ki-67 Expression and Mitotic Count in Lymph Node Metastases from Breast Cancer.PloS one · 2016Article
- Clinical and Pathological Characteristics of Patients With Papillary Thyroid Carcinoma Coexisting With Hashimoto's Thyroiditis: A Retrospective Cohort Study.Cancer control : journal of the Moffitt Cancer CenterArticle
- Image Findings of Breast Cancer-Related Elastosis: A Case Report.Case reports in oncologyArticle
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10 authors at 5 institutions in 1 country.
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Abstract
backgroundMammography screen-detected breast cancers have a better prognosis than predicted from established prognostic markers. A search for additional features that are characteristic for these tumours and their prognosis is needed to reduce overtreatment, a recognized challenge in breast cancer patient management today. Here, we have investigated the occurrence and importance of tumour elastosis.
methodsWe performed a population based retrospective study of breast cancers detected in the Norwegian Breast Cancer Screening Programme in Vestfold County during 2004-2009. In total, 197 invasive screen-detected cancers and 75 interval cancers in patients aged 50-69 years were compared with regard to standard clinico-pathological parameters and tumour shape, as well as ER, PR, HER2 and Ki67 expression. In particular, the presence of elastotic material in tumours was graded on a 4-tiered scale (score 0-3).
resultsScreen-detected cancers had a significantly higher content of stromal elastosis than interval cancers (p < 0.001). High content of elastosis (score 3) correlated strongly with stellate tumour shape, low histological grade, and ER+/HER2- status. Further, high elastosis score was significantly associated with lower Ki67 expression. In survival analyses, cases with high elastosis demonstrated increased recurrence free (p = 0.03) and disease-specific survival (p = 0.11) compared to cases with low elastosis.
conclusionThere is a strong correlation between the presence of tumour elastosis, stellate tumour shape and mammography detection of breast cancers. To our knowledge, this is the first time elastosis has been studied in relation to breast cancer detection method. Presence of elastosis is associated with low tumour cell proliferation (Ki67) and a good prognosis. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_230.
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