ArticleMicrobes and infection2015
Commensal Streptococcus mitis is a unique vector for oral mucosal vaccination.
Article in Microbes and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Evaluation of immune response toParasitology · 2020Article
- Intranasal Immunization with the CommensalApplied and environmental microbiology · 2019Article
- The current status, challenges, and future developments of new tuberculosis vaccines.Human vaccines & immunotherapeutics · 2018Review
- High-resolution profiles of the Streptococcus mitis CSP signaling pathway reveal core and strain-specific regulated genes.BMC genomics · 2018Article
- Late-onset bleb-associated endophthalmitis and continuous positive airway pressure.American journal of ophthalmology case reports · 2018Article
- Immunogenic Properties of Lactobacillus plantarum Producing Surface-Displayed Mycobacterium tuberculosis Antigens.Applied and environmental microbiology · 2017Article
- Exploring Host-Commensal Interactions in the Respiratory Tract.Frontiers in immunology · 2017Review
- Non-pathogenic microflora of a spring water with regenerative properties.Biomedical reports · 2015Article
- Oral delivery of Bacillus subtilis spore expressing enolase of Clonorchis sinensis in rat model: induce systemic and local mucosal immune responses and has no side effect on liver function.Parasitology research · 2015Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The development of vaccine approaches that induce mucosal and systemic immune responses is critical for the effective prevention of several infections. Here, we report on the use of the abundant human oral commensal bacterium Streptococcus mitis as a delivery vehicle for mucosal immunization. Using homologous recombination we generated a stable rS. mitis expressing a Mycobacterium tuberculosis protein (Ag85b). Oral administration of rS. mitis in gnotobiotic piglets resulted in efficient oral colonization and production of oral and systemic anti-Ag85b specific IgA and IgG antibodies. These results support that the commensal S. mitis is potentially a useful vector for mucosal vaccination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.