ArticleBMC plant biology2014
Microbe-associated molecular pattern-induced calcium signaling requires the receptor-like cytoplasmic kinases, PBL1 and BIK1.
Article in BMC plant biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62 citing papers in PubMed, 130 citations in OpenAlex.
- Identifying anthracnose resistance genes involving in ROS and JA accumulation.Plant signaling & behavior · 2026Article
- The F-box Containing Bacterial Effector RipG6 Destabilizes a Receptor-Like Cytoplasmic Kinase Involved in Plant Immune Signaling.The plant pathology journal · 2026Article
- Salicylic acid: a key natural foundation for next-generation plant defense stimulators.Pest management science · 2026Review
- New alleles of Arabidopsis BIK1 reinforce its predominant role in pattern-triggered immunity and caution interpretations of other reported functions.Nature plants · 2026Article
- The function of the Arabidopsis receptor kinase THESEUS1 in plant cell wall integrity maintenance: from evolutionary origin to future perspectives.The Plant journal : for cell and molecular biology · 2026Review
- CEPR2 perceives group II CEPs to regulate cell surface receptor-mediated immunity in Arabidopsis.PLoS pathogens · 2025Article
- Receptor-like cytoplasmic kinases mediated signaling in plant immunity: convergence and divergence.Stress biology · 2025Review
- Allosteric activation of the co-receptor BAK1 by the EFR receptor kinase initiates immune signaling.eLife · 2024Article
- Plant Immunity: At the Crossroads of Pathogen Perception and Defense Response.Plants (Basel, Switzerland) · 2024Review
- Functional screening of the Arabidopsis 2C protein phosphatases family identifies PP2C15 as a negative regulator of plant immunity by targeting BRI1-associated receptor kinase 1.Molecular plant pathology · 2024Article
- Article
- Subtilase-mediated biogenesis of the expanded family of SERINE RICH ENDOGENOUS PEPTIDES.Nature plants · 2023Article
- The PTI-suppressing Avr2 effector from Fusarium oxysporum suppresses mono-ubiquitination and plasma membrane dissociation of BIK1.Molecular plant pathology · 2023Article
- Paradigms of receptor kinase signaling in plants.The Biochemical journal · 2023Review
- N-hydroxypipecolic acid primes plants for enhanced microbial pattern-induced responses.Frontiers in plant science · 2023Article
- The calcium connection: exploring the intricacies of calcium signaling in plant-microbe interactions.Frontiers in plant science · 2023Review
- Plant elicitor peptide 1 fortifies root cell walls and triggers a systemic root-to-shoot immune signaling inPlant signaling & behavior · 2022Article
- The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 and is targeted by a bacterial type-III effector.The EMBO journal · 2022Article
- DIACYLGLYCEROL KINASE 5 participates in flagellin-induced signaling in Arabidopsis.Plant physiology · 2022Article
- What's new in protein kinase/phosphatase signalling in the control of plant immunity?Essays in biochemistry · 2022Review
2 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlant perception of conserved microbe-derived or damage-derived molecules (so-called microbe- or damage-associated molecular patterns, MAMPs or DAMPs, respectively) triggers cellular signaling cascades to initiate counteracting defence responses. Using MAMP-induced rise in cellular calcium levels as one of the earliest biochemical readouts, we initiated a genetic screen for components involved in early MAMP signaling in Arabidopsis thaliana.
resultsWe characterized here the "changed calcium elevation 5" (cce5) mutant, where five allelic cce5 mutants were isolated. They all show reduced calcium levels after elicitation with peptides representing bacteria-derived MAMPs (flg22 and elf18) and endogenous DAMP (AtPep1), but a normal response to chitin octamers. Mapping, sequencing of the mutated locus and complementation studies revealed CCE5 to encode the receptor-like cytoplasmic kinase (RLCK), avrPphB sensitive 1-like 1 (PBL1). Kinase activities of PBL1 derived from three of the cce5 alleles are abrogated in vivo. Validation with T-DNA mutants revealed that, besides PBL1, another RLCK, Botrytis-induced kinase 1 (BIK1), is also required for MAMP/DAMP-induced calcium elevations.
conclusionsHence, PBL1 and BIK1 (but not two related RLCKs, PBS1 and PBL2) are required for MAMP/DAMP-induced calcium signaling. It remains to be investigated if the many other RLCKs encoded in the Arabidopsis genome affect early calcium signal transduction - perhaps in dependence on the type of MAMP/DAMP ligands. A future challenge would be to identify the substrates of these various RLCKs, in order to elucidate their signaling role between the receptor complexes at the plasma membrane and downstream cellular signaling components.
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