ArticleCell research2015
SCF(Slmb) E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila.
Article in Cell research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- PP2A phosphatase regulates Hippo signalling in dual manner.The EMBO journal · 2026Article
- Reversible acetylation of Hpo regulates the Hippo pathway.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The deubiquitylating enzyme Fat facets promotes Fat signalling and restricts tissue growth.Nature communications · 2025Article
- Activation of lysophagy by a TBK1-SCFNature communications · 2025Article
- E2 enzyme Bruce negatively regulates Hippo signaling through POSH-mediated expanded degradation.Cell death & disease · 2023Article
- Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathway.The Journal of cell biology · 2023Article
- Shaggy regulates tissue growth through Hippo pathway in Drosophila.Science China. Life sciences · 2022Article
- Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.PLoS genetics · 2021Article
- Article
- Fat-regulated adaptor protein Dlish binds the growth suppressor Expanded and controls its stability and ubiquitination.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded.Developmental cell · 2017Article
- CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.Cell death & disease · 2017Article
- Article
- A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth.Nature communications · 2016Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Deregulation of the evolutionarily conserved Hippo pathway has been implicated in abnormal development of animals and in several types of cancer. One mechanism of Hippo pathway regulation is achieved by controlling the stability of its regulatory components. However, the executive E3 ligases that are involved in this process, and how the process is regulated, remain poorly defined. In this study, we identify, through a genetic candidate screen, the SCF(Slmb) E3 ligase as a novel negative regulator of the Hippo pathway in Drosophila imaginal tissues via mediation of the degradation of Expanded (Ex). Mechanistic study shows that Slmb-mediated degradation of Ex is inhibited by the Hippo signaling. Considering the fact that Hippo signaling suppresses the transcription of ex, we propose that the Hippo pathway employs a double security mechanism to ensure fine-tuned homeostasis during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.