ArticleNatural product communications2014
Antiproliferative and antimalarial sesquiterpene lactones from Piptocoma antillana from Puerto Rico.
Article in Natural product communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Antiplasmodial natural products: an update.Malaria journal · 2019Review
- Antiplasmodial Diterpenoids and a Benzotropolone from Petradoria pumila.Journal of natural products · 2018Article
- Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest.Journal of natural products · 2015Article
- Antimalarial 5,6-Dihydro-α-pyrones from Cryptocarya rigidifolia: Related Bicyclic Tetrahydro-α-Pyrones Are Artifacts1.Journal of natural products · 2015Article
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Authors and funding
7 authors.
Funding
Abstract
Bioassay-directed fractionation of an antiproliferative ethanol extract of the leaves and twigs of Piptocoma antillana (Asteraceae) afforded two new goyazensolide-type sesquiterpene lactones named 5-O-methyl-5-epiisogoyazensolide (1) and 15-O-methylgoyazensolide (2), together with the known compounds 1-oxo-3,10-epoxy-8-(2-methylacr1 0-epoxy-8-(2-methylacryloxy)-l 5-acetoxygermacra-2,4, 11(1 3)-trien-6(12)-olide (3) and 5-epiisogoyazensolide (4). The structure elucidation of all compounds was carried out based on NMR and mass spectroscopic data analyses. The relative and absolute configurations of all the isolated compounds were determined from their CD and NOESY NMR spectra. Compounds 1-4 showed moderately potent antiproliferative activities against A2780 ovarian cancer cells, with IC50 values of 1.5 +0.5, 0.6 ± 0.3, 1.62 ± 0.05, and 1.56 ± 0.04 μM, respectively. They also displayed antimalarial activity against Plasmodiumfalciparum, with IC50 values of 6.2 05 22 ± 0.5, 2.2± 0.5, 8.0 ± 0.4, and 9.0 ± 0.6 μM, respectively.
Indexed as
Identifiers
25522525PMC4311553What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.