Evidence map›Paper›PMID 25522424›Full record

ArticleThe international journal of neuropsychopharmacology2014

The role of BDNF, leptin, and catecholamines in reward learning in bulimia nervosa.

Philipp Homan, Simona Grob, Gabriella Milos, Ulrich Schnyder, Anne Eckert, Undine Lang, Gregor Hasler

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. KoreanNutrition research and practice · 2016
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Philipp HomanDepartment of Molecular Psychiatry, University Hospital of Psychiatry, University of Bern, Switzerland (Drs Homan and Hasler); Department of Psychiatry and Psychotherapy, University Hospital, Zurich, Switzerland (Dr Grob, Drs Milos and Schnyder); Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics Basel, Switzerland (Dr Eckert); Psychiatric University Clinics Basel, Switzerland (Dr Lang). homan@puk.unibe.ch.
Simona GrobDepartment of Molecular Psychiatry, University Hospital of Psychiatry, University of Bern, Switzerland (Drs Homan and Hasler); Department of Psychiatry and Psychotherapy, University Hospital, Zurich, Switzerland (Dr Grob, Drs Milos and Schnyder); Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics Basel, Switzerland (Dr Eckert); Psychiatric University Clinics Basel, Switzerland (Dr Lang).
Gabriella MilosDepartment of Molecular Psychiatry, University Hospital of Psychiatry, University of Bern, Switzerland (Drs Homan and Hasler); Department of Psychiatry and Psychotherapy, University Hospital, Zurich, Switzerland (Dr Grob, Drs Milos and Schnyder); Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics Basel, Switzerland (Dr Eckert); Psychiatric University Clinics Basel, Switzerland (Dr Lang).
Ulrich SchnyderDepartment of Molecular Psychiatry, University Hospital of Psychiatry, University of Bern, Switzerland (Drs Homan and Hasler); Department of Psychiatry and Psychotherapy, University Hospital, Zurich, Switzerland (Dr Grob, Drs Milos and Schnyder); Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics Basel, Switzerland (Dr Eckert); Psychiatric University Clinics Basel, Switzerland (Dr Lang).
Anne EckertDepartment of Molecular Psychiatry, University Hospital of Psychiatry, University of Bern, Switzerland (Drs Homan and Hasler); Department of Psychiatry and Psychotherapy, University Hospital, Zurich, Switzerland (Dr Grob, Drs Milos and Schnyder); Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics Basel, Switzerland (Dr Eckert); Psychiatric University Clinics Basel, Switzerland (Dr Lang).
Undine LangDepartment of Molecular Psychiatry, University Hospital of Psychiatry, University of Bern, Switzerland (Drs Homan and Hasler); Department of Psychiatry and Psychotherapy, University Hospital, Zurich, Switzerland (Dr Grob, Drs Milos and Schnyder); Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics Basel, Switzerland (Dr Eckert); Psychiatric University Clinics Basel, Switzerland (Dr Lang).
Gregor HaslerDepartment of Molecular Psychiatry, University Hospital of Psychiatry, University of Bern, Switzerland (Drs Homan and Hasler); Department of Psychiatry and Psychotherapy, University Hospital, Zurich, Switzerland (Dr Grob, Drs Milos and Schnyder); Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics Basel, Switzerland (Dr Eckert); Psychiatric University Clinics Basel, Switzerland (Dr Lang).
University of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA relationship between bulimia nervosa and reward-related behavior is supported by several lines of evidence. The dopaminergic dysfunctions in the processing of reward-related stimuli have been shown to be modulated by the neurotrophin brain derived neurotrophic factor (BDNF) and the hormone leptin.

methodsUsing a randomized, double-blind, placebo-controlled, crossover design, a reward learning task was applied to study the behavior of 20 female subjects with remitted bulimia nervosa and 27 female healthy controls under placebo and catecholamine depletion with alpha-methyl-para-tyrosine (AMPT). The plasma levels of BDNF and leptin were measured twice during the placebo and the AMPT condition, immediately before and 1 hour after a standardized breakfast.

resultsAMPT-induced differences in plasma BDNF levels were positively correlated with the AMPT-induced differences in reward learning in the whole sample (P=.05). Across conditions, plasma brain derived neurotrophic factor levels were higher in remitted bulimia nervosa subjects compared with controls (diagnosis effect; P=.001). Plasma BDNF and leptin levels were higher in the morning before compared with after a standardized breakfast across groups and conditions (time effect; P<.0001). The plasma leptin levels were higher under catecholamine depletion compared with placebo in the whole sample (treatment effect; P=.0004).

conclusionsThis study reports on preliminary findings that suggest a catecholamine-dependent association of plasma BDNF and reward learning in subjects with remitted bulimia nervosa and controls. A role of leptin in reward learning is not supported by this study. However, leptin levels were sensitive to a depletion of catecholamine stores in both remitted bulimia nervosa and controls.

Indexed as

Association LearningRewardAdultalpha-MethyltyrosineBody Mass IndexBrain-Derived Neurotrophic FactorBulimia NervosaCatecholaminesCross-Over StudiesDouble-Blind MethodFemaleHumansLeptinNeuropsychological TestsRandom AllocationYoung Adultalpha-MethyltyrosineBrain-Derived Neurotrophic FactorCatecholaminesLeptinalpha-methyl-para-tyrosineBDNFbulimia nervosacatecholaminesleptinreward

Identifiers

PMID25522424
PMCPMC4376547
OpenAlexW2134955801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.