Evidence map›Paper›PMID 25522404›Full record

ArticleThe international journal of neuropsychopharmacology2014

A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats.

Carmelo Millón, Antonio Flores-Burgess, Manuel Narváez, Dasiel O Borroto-Escuela, Luis Santín, Concepción Parrado, José Angel Narváez, Kjell Fuxe, Zaida Díaz-Cabiale

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Anxiety and Depression: What Do We Know of Neuropeptides?Behavioral sciences (Basel, Switzerland) · 2022
    Review
  6. Review
  7. Article
  8. Serum Galanin in Children with Autism Spectrum Disorder.Child psychiatry and human development · 2022
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Association Between Polymorphisms in the 5' Region of theNeuropsychiatric disease and treatment · 2020
    Article
  16. Review
  17. Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Carmelo MillónUniversidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Campus de Teatinos s/n, 29071 Málaga, España (PhD Millón, Flores-Burgess, M Narváez, Parrado, JA Narváez, and Díaz-Cabiale); Department of Neuroscience, Karolinska Institute, Stockholm, Sweden (PhD Borroto-Escuela and Fuxe); Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Psicología, Campus de Teatinos s/n, 29071 Málaga, España (PhD Santín).
Antonio Flores-BurgessUniversidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Campus de Teatinos s/n, 29071 Málaga, España (PhD Millón, Flores-Burgess, M Narváez, Parrado, JA Narváez, and Díaz-Cabiale); Department of Neuroscience, Karolinska Institute, Stockholm, Sweden (PhD Borroto-Escuela and Fuxe); Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Psicología, Campus de Teatinos s/n, 29071 Málaga, España (PhD Santín).
Manuel NarváezUniversidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Campus de Teatinos s/n, 29071 Málaga, España (PhD Millón, Flores-Burgess, M Narváez, Parrado, JA Narváez, and Díaz-Cabiale); Department of Neuroscience, Karolinska Institute, Stockholm, Sweden (PhD Borroto-Escuela and Fuxe); Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Psicología, Campus de Teatinos s/n, 29071 Málaga, España (PhD Santín).
Dasiel O Borroto-EscuelaUniversidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Campus de Teatinos s/n, 29071 Málaga, España (PhD Millón, Flores-Burgess, M Narváez, Parrado, JA Narváez, and Díaz-Cabiale); Department of Neuroscience, Karolinska Institute, Stockholm, Sweden (PhD Borroto-Escuela and Fuxe); Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Psicología, Campus de Teatinos s/n, 29071 Málaga, España (PhD Santín).
Luis SantínUniversidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Campus de Teatinos s/n, 29071 Málaga, España (PhD Millón, Flores-Burgess, M Narváez, Parrado, JA Narváez, and Díaz-Cabiale); Department of Neuroscience, Karolinska Institute, Stockholm, Sweden (PhD Borroto-Escuela and Fuxe); Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Psicología, Campus de Teatinos s/n, 29071 Málaga, España (PhD Santín).
Concepción ParradoUniversidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Campus de Teatinos s/n, 29071 Málaga, España (PhD Millón, Flores-Burgess, M Narváez, Parrado, JA Narváez, and Díaz-Cabiale); Department of Neuroscience, Karolinska Institute, Stockholm, Sweden (PhD Borroto-Escuela and Fuxe); Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Psicología, Campus de Teatinos s/n, 29071 Málaga, España (PhD Santín).
José Angel NarváezUniversidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Campus de Teatinos s/n, 29071 Málaga, España (PhD Millón, Flores-Burgess, M Narváez, Parrado, JA Narváez, and Díaz-Cabiale); Department of Neuroscience, Karolinska Institute, Stockholm, Sweden (PhD Borroto-Escuela and Fuxe); Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Psicología, Campus de Teatinos s/n, 29071 Málaga, España (PhD Santín).
Kjell FuxeUniversidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Campus de Teatinos s/n, 29071 Málaga, España (PhD Millón, Flores-Burgess, M Narváez, Parrado, JA Narváez, and Díaz-Cabiale); Department of Neuroscience, Karolinska Institute, Stockholm, Sweden (PhD Borroto-Escuela and Fuxe); Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Psicología, Campus de Teatinos s/n, 29071 Málaga, España (PhD Santín).
Zaida Díaz-CabialeUniversidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Medicina, Campus de Teatinos s/n, 29071 Málaga, España (PhD Millón, Flores-Burgess, M Narváez, Parrado, JA Narváez, and Díaz-Cabiale); Department of Neuroscience, Karolinska Institute, Stockholm, Sweden (PhD Borroto-Escuela and Fuxe); Universidad de Málaga, Instituto de Investigación Biomédica de Málaga, Facultad de Psicología, Campus de Teatinos s/n, 29071 Málaga, España (PhD Santín). zaida@uma.es.
Karolinska Institutet · SEInstituto de Investigación Biomédica de Málaga · ESUniversidad de Málaga · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGalanin (GAL) plays a role in mood regulation. In this study we analyzed the action of the active N-terminal fragment [GAL(1-15)] in anxiety- and depression-related behavioral tests in rats.

methodsThe effect of GAL(1-15) was analyzed in the forced swimming test, tail suspension test, open field test, and light/dark test. The proximity of GAL1 and GAL2 receptors was examined with the proximity ligation assay (PLA). We tested the GAL receptors involved in GAL(1-15) effects with the GAL2 receptor antagonist M871 and with an in vivo model of siRNA GAL2 receptor knockdown or siRNA GAL1 receptor knockdown rats. The effects of GAL(1-15) were also studied in the cell line RN33B.

resultsGAL(1-15) induced strong depression-like and anxiogenic-like effects in all the tests. These effects were stronger than the ones induced by GAL. The involvement of the GAL2 receptor was demonstrated with M871 and with the siRNA GAL2 receptor knockdown rats. The PLA indicated the possible existence of GAL1 and GAL2 heteroreceptor complexes in the dorsal hippocampus and especially in the dorsal raphe nucleus. In the siRNA GAL1 receptor knockdown rats the behavioral actions of GAL(1-15) disappeared, and in the siRNA GAL2 receptor knockdown rats the reductions of the behavioral actions of GAL(1-15) was linked to a disappearance of PLA. In the cell line RN33B, GAL(1-15) decreased 5-HT immunoreactivity more strongly than GAL.

conclusionsOur results indicate that GAL(1-15) exerts strong depression-related and anxiogenic-like effects and may give the basis for the development of drugs targeting GAL1 and GAL2 heteroreceptor complexes in the raphe-limbic system for the treatment of depression and anxiety.

Indexed as

AnimalsAnxietyCell Line, TransformedDark AdaptationDepressionDose-Response Relationship, DrugExploratory BehaviorGalaninGene Expression RegulationHippocampusMalePeptide FragmentsRaphe NucleiRatsRats, Sprague-DawleyRats, TransgenicGalaninPeptide FragmentsReceptor, Galanin, Type 1Receptor, Galanin, Type 2Serotoninanxietydepressiongalanin

Identifiers

PMID25522404
PMCPMC4360234
OpenAlexW2183216728

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.