Trial reportThe international journal of neuropsychopharmacology2014
Oxytocin affects the connectivity of the precuneus and the amygdala: a randomized, double-blinded, placebo-controlled neuroimaging trial.
Trial report in The international journal of neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Oxytocinergic modulation of speech production-a double-blind placebo-controlled fMRI study.Social cognitive and affective neuroscience · 2023Trial
- Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men.Scientific reports · 2023Trial
- Oxytocinergic Modulation of Stress-Associated Amygdala-Hippocampus Pathways in Humans Is Mediated by Serotonergic Mechanisms.The international journal of neuropsychopharmacology · 2022Trial
- Intranasal oxytocin modulates the salience network in aging.NeuroImage · 2022Trial
- Oxytocin modulates the effective connectivity between the precuneus and the dorsolateral prefrontal cortex.European archives of psychiatry and clinical neuroscience · 2020Trial
- Common and dissociable effects of oxytocin and lorazepam on the neurocircuitry of fear.Proceedings of the National Academy of Sciences of the United States of America · 2020Trial
- Oxytocin Enhances an Amygdala Circuit Associated With Negative Symptoms in Schizophrenia: A Single-Dose, Placebo-Controlled, Crossover, Randomized Control Trial.Schizophrenia bulletin · 2020Trial
- Intranasal Oxytocin Selectively Modulates Large-Scale Brain Networks in Humans.Brain connectivity · 2017Trial
- Amygdala Connectivity Alterations in High Myopia: A Resting-State fMRI Study with SVM-Based Classification.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Personality Traits Induce Different Brain Patterns When Processing Social and Valence Information.Frontiers in psychology · 2021Article
- Article
- Spontaneous brain state oscillation is associated with self-reported anxiety in a non-clinical sample.Scientific reports · 2020Article
- Imaging of intranasal drug delivery to the brain.American journal of nuclear medicine and molecular imaging · 2020Review
- Neural correlates of oxytocin and cue reactivity in cocaine-dependent men and women with and without childhood trauma.Psychopharmacology · 2019Article
- Design of a randomized controlled trial examining the efficacy of oxytocin to enhance alcohol behavioral couple therapy.Contemporary clinical trials · 2019Article
- Impact of Oxytocin on the neural correlates of fearful face processing in PTSD related to childhood Trauma.European journal of psychotraumatology · 2019Article
- Intranasal oxytocin modulates neural functional connectivity during human social interaction.American journal of primatology · 2018Article
- The Neuropeptide Hormone Oxytocin in Eating Disorders.Current psychiatry reports · 2018Review
- Confused Connections? Targeting White Matter to Address Treatment Resistant Schizophrenia.Frontiers in pharmacology · 2018Review
- Sex differences in associations of arginine vasopressin and oxytocin with resting-state functional brain connectivity.Journal of neuroscience research · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundAlthough oxytocin is one of the most widely studied neuropeptides in recent times, the mechanistic process by which it modulates social-affective behavior in the brain is not yet clearly understood. Thus, to understand the neurophysiological basis of oxytocin effects, we used resting-state functional MRI to examine the effects of intranasal oxytocin on brain connectivity in healthy males.
methodsUsing a randomized, double-blinded, placebo-controlled, crossover design, 15 healthy male volunteers received 24 IU intranasal oxytocin or placebo prior to resting-state functional MRI acquisition at 3T.
resultsWe found that oxytocin significantly reduced the degree centrality of the right precuneus (P<.05). Oxytocin also reduced connectivity between the bilateral amygdalae and between the right precuneus and the right and left amygdala (P<.05). Although there were no significant changes in regional homogeneity at the whole brain level, posthoc results showed a reduction involving the right precuneus (P<.05).
conclusionsThese results show that oxytocin affects one of the key centers in the brain for social cognition and introspective processing, the precuneus, and enhances our understanding of how oxytocin can modulate brain networks at rest. An improved understanding of the neurophysiological effects of oxytocin can be important in terms of evaluating the mechanisms that are likely to underlie the clinical responses observed upon long-term oxytocin administration.
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