ArticleJournal of the American Chemical Society2015
Ligand-receptor interaction catalyzes the aggregation of small molecules to induce cell necroptosis.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 48 citations in OpenAlex.
- HydrogelFinder: A Foundation Model for Efficient Self-Assembling Peptide Discovery Guided by Non-Peptidal Small Molecules.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Hierarchically Compartmentalized Supramolecular Gels through Multilevel Self-Sorting.Journal of the American Chemical Society · 2019Article
- Instructed-Assembly (iA): A Molecular Process for Controlling Cell Fate.Bulletin of the Chemical Society of Japan · 2018Article
- Supramolecular catalysis and dynamic assemblies for medicine.Chemical Society reviews · 2017Review
- Supramolecular biofunctional materials.Biomaterials · 2017Review
- Bioinspired assembly of small molecules in cell milieu.Chemical Society reviews · 2017Review
- Internal Structure and Preferential Protein Binding of Colloidal Aggregates.ACS chemical biology · 2017Article
- Ligand-Receptor Interaction Modulates the Energy Landscape of Enzyme-Instructed Self-Assembly of Small Molecules.Journal of the American Chemical Society · 2016Article
- Heterotypic Supramolecular Hydrogels.Journal of materials chemistry. B · 2016Article
- Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.Chemical reviews · 2015Review
- Gelation Landscape Engineering Using a Multi-Reaction Supramolecular Hydrogelator System.Journal of the American Chemical Society · 2015Article
- Biocompatible fluorescent supramolecular nanofibrous hydrogel for long-term cell tracking and tumor imaging applications.Scientific reports · 2015Article
- Nanoscale Assemblies of Small Molecules Control the Fate of Cells.Nano today · 2015Article
- Supramolecular Detoxification of Neurotoxic Nanofibrils of Small Molecules via Morphological Switch.Bioconjugate chemistry · 2015Article
- Enzyme transformation to modulate the ligand-receptor interactions between small molecules.Chemical communications (Cambridge, England) · 2015Article
- Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Because they exhibit important biological functions, from unfolding proteins to activating enzymes to controlling cell fates, aggregates of small molecules are able to serve as functional molecular entities in cellular environments. However, the inability to precisely control their production has hampered the understanding and exploration of their biological functions. Here we show that the well-established ligand-receptor interaction between vancomycin and d-Ala-d-Ala catalyzes the aggregation of a d-Ala-d-Ala-containing small peptide derivative in water. The resulting aggregates largely adhere to the cell surface to induce cell necroptosis. Mutation of d-Ala-d-Ala to l-Ala-l-Ala or removal of the aromatic group in the derivative results in innocuous compounds, confirming that the aromatic-aromatic and ligand-receptor interactions are responsible for the formation and corresponding cytotoxicity of the aggregates. In addition to being the first example of ligand-receptor interaction-catalyzed aggregation of small molecules on the surface of mammalian cells, this work provides useful insights for understanding the cytotoxicity of molecular aggregates of small molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.