Observational studyAmerican journal of respiratory and critical care medicine2015
Lung cancer in patients with chronic obstructive pulmonary disease. Development and validation of the COPD Lung Cancer Screening Score.
Observational study in American journal of respiratory and critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recommendations from the European Society of Thoracic Surgeons (ESTS) regarding computed tomography screening for lung cancer in Europe.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2017Guideline
- Chronic obstructive pulmonary disease prevalence and prediction in a high-risk lung cancer screening population.BMC pulmonary medicine · 2020Trial
- Trial
- Integration of circulating tumor DNA data enhances lung cancer prediction in patients with COPD.Scientific reports · 2026Article
- Prospective COPD Case Finding in a Lung Cancer Screening Program: A Pilot Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- Incidence of Lung Cancer in COPD Patients in Western Yokohama Managed by Primary Care Physicians with Hospital Collaboration.International journal of chronic obstructive pulmonary disease · 2025Article
- Integrating genetic and clinical data to predict lung cancer in patients with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2024Article
- Emphysema and lung cancer risk.Translational lung cancer research · 2024Article
- Decoding LncRNA in COPD: Unveiling Prognostic and Diagnostic Power and Their Driving Role in Lung Cancer Progression.International journal of molecular sciences · 2024Review
- COPD With Lung Cancer Among Older United States Adults: Prevalence, Diagnostic Timeliness, and Association With Earlier Stage Tumors.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- Impact of smoking reduction on lung cancer risk in patients with COPD who smoked fewer than 30 pack-years: a nationwide population-based cohort study.Respiratory research · 2024Article
- Article
- Sex differences in chronic obstructive pulmonary disease characteristics: the Korea National Health and Nutrition Examination Survey 2007-2018.The Korean journal of internal medicine · 2024Article
- The Diagnostic Value of Systemic Immune-Inflammatory Index (SII) and Lymphocyte-Albumin-Neutrophil Ratio (LANR) in Chronic Obstructive Pulmonary Disease with Lung Cancer.Journal of inflammation research · 2024Article
- Epithelial-mesenchymal transition changes in nonsmall cell lung cancer patients with early COPD.ERJ open research · 2023Article
- Radiomic phenotyping of the lung parenchyma in a lung cancer screening cohort.Scientific reports · 2023Article
- Toll-like receptors 2, 4, and 9 modulate promoting effect of COPD-like airway inflammation on K-ras-driven lung cancer through activation of the MyD88/NF-ĸB pathway in the airway epithelium.Frontiers in immunology · 2023Article
- Lung function impairment in the German Lung Cancer Screening Intervention Study (LUSI): prevalence, symptoms, and associations with lung cancer risk, tumor histology and all-cause mortality.Translational lung cancer research · 2022Article
- Complex Relationship between Bronchiectasis and Lung Cancer.Annals of the American Thoracic Society · 2022Article
- Lung Cancer Screening in Individuals With and Without Lung-Related Comorbidities.JAMA network open · 2022Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
rationalePatients with chronic obstructive pulmonary disease (COPD) are at high risk for lung cancer (LC) and represent a potential target to improve the diagnostic yield of screening programs.
objectivesTo develop a predictive score for LC risk for patients with COPD.
methodsThe Pamplona International Early Lung Cancer Detection Program (P-IELCAP) and the Pittsburgh Lung Screening Study (PLuSS) databases were analyzed. Only patients with COPD on spirometry were included. By logistic regression we determined which factors were independently associated with LC in PLuSS and developed a COPD LC screening score (COPD-LUCSS) to be validated in P-IELCAP. MEASUREMENTS AND MAIN
resultsBy regression analysis, age greater than 60, body mass index less than 25 kg/m(2), pack-years history greater than 60, and emphysema presence were independently associated with LC diagnosis and integrated into the COPD-LUCSS, which ranges from 0 to 10 points. Two COPD-LUCSS risk categories were proposed: low risk (scores 0-6) and high risk (scores 7-10). In comparison with low-risk patients, in both cohorts LC risk increased 3.5-fold in the high-risk category.
conclusionsThe COPD-LUCSS is a good predictor of LC risk in patients with COPD participating in LC screening programs. Validation in two different populations adds strength to the findings.
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