ArticlePloS one2014
Nanotopography alters nuclear protein expression, proliferation and differentiation of human mesenchymal stem/stromal cells.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Considering the Value of 3D Cultures for Enhancing the Understanding of Adhesion, Proliferation, and Osteogenesis on Titanium Dental Implants.Biomolecules · 2023Article
- Getting physical: Material mechanics is an intrinsic cell cue.Cell stem cell · 2023Review
- Assessing the Efficacy of Whole-Body Titanium Dental Implant Surface Modifications in Inducing Adhesion, Proliferation, and Osteogenesis in Human Adipose Tissue Stem Cells.Journal of functional biomaterials · 2022Article
- Surface Topography of Titanium Affects Their Osteogenic Potential through DNA Methylation.International journal of molecular sciences · 2021Article
- The role of lamin A/C in mesenchymal stem cell differentiation.Journal of physiology and biochemistry · 2019Review
- Directional Topography Influences Adipose Mesenchymal Stromal Cell Plasticity: Prospects for Tissue Engineering and Fibrosis.Stem cells international · 2019Article
- Shaping Cell Fate: Influence of Topographical Substratum Properties on Embryonic Stem Cells.Tissue engineering. Part B, Reviews · 2018Review
- Human mesenchymal stem cell basal membrane bending on gratings is dependent on both grating width and curvature.Scientific reports · 2018Article
- Surface functionalisation of nanodiamonds for human neural stem cell adhesion and proliferation.Scientific reports · 2017Article
- Biophysical Regulation of Cell Behavior-Cross Talk between Substrate Stiffness and Nanotopography.Engineering (Beijing, China) · 2017Article
- Nanotopographical Modulation of Cell Function through Nuclear Deformation.ACS applied materials & interfaces · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Mesenchymal stem/stromal cells respond to physical cues present in their microenvironment such as substrate elasticity, geometry, or topography with respect to morphology, proliferation, and differentiation. Although studies have demonstrated the role of focal adhesions in topography-mediated changes of gene expression, information linking substrate topography to the nucleus remains scarce. Here we show by two-dimensional gel electrophoresis and western blotting that A-type lamins and retinoblastoma protein are downregulated in mesenchymal stem/stromal cells cultured on 350 nm gratings compared to planar substrates; these changes lead to a decrease in proliferation and changes in differentiation potential.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.