ArticleJournal of the American Chemical Society2015
Generation of functional RNAs from inactive oligonucleotide complexes by non-enzymatic primer extension.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Evolution from Composome to RNA Replicase.Life (Basel, Switzerland) · 2026Review
- Polymerization and replication of primordial RNA induced by clay-water interface dynamics.Communications chemistry · 2025Article
- Assembly of catalytic complexes from randomized oligonucleotides.Science advances · 2025Article
- Biomimetic Materials to Fabricate Artificial Cells.Chemical reviews · 2024Review
- Biological Catalysis and Information Storage Have Relied onBiomolecules · 2023Review
- An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination.Nature chemistry · 2022Article
- A Fluorescent G-Quadruplex Sensor for Chemical RNA Copying.Angewandte Chemie (International ed. in English) · 2018Article
- Physical Principles and Extant Biology Reveal Roles for RNA-Containing Membraneless Compartments in Origins of Life Chemistry.Biochemistry · 2018Article
- Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution.Small (Weinheim an der Bergstrasse, Germany) · 2018Article
- Amplification of RNA by an RNA polymerase ribozyme.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A simple physical mechanism enables homeostasis in primitive cells.Nature chemistry · 2016Article
- Collaboration between primitive cell membranes and soluble catalysts.Nature communications · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The earliest genomic RNAs had to be short enough for efficient replication, while simultaneously serving as unfolded templates and effective ribozymes. A partial solution to this paradox may lie in the fact that many functional RNAs can self-assemble from multiple fragments. Therefore, in early evolution, genomic RNA fragments could have been significantly shorter than unimolecular functional RNAs. Here, we show that unstable, nonfunctional complexes assembled from even shorter 3'-truncated oligonucleotides can be stabilized and gain function via non-enzymatic primer extension. Such short RNAs could act as good templates due to their minimal length and complex-forming capacity, while their minimal length would facilitate replication by relatively inefficient polymerization reactions. These RNAs could also assemble into nascent functional RNAs and undergo conversion to catalytically active forms, by the same polymerization chemistry used for replication that generated the original short RNAs. Such phenomena could have substantially relaxed requirements for copying efficiency in early nonenzymatic replication systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.