ArticlePLoS genetics2014
SEEDSTICK is a master regulator of development and metabolism in the Arabidopsis seed coat.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 110 citations in OpenAlex.
- ARABIDOPSIS Bsister and SEEDSTICK MADS-box transcription factors modulate maternal nutrient flow for seed development in Arabidopsis.Nature communications · 2026Article
- A transcriptional atlas of early Arabidopsis seed development suggests mechanisms for inter-tissue coordination.Nature plants · 2026Article
- Integrative gene expression and heterologous functional analysis identify candidate regulators of apomixis inFrontiers in plant science · 2026Article
- Genome-wide association study to identification of candidate genes influencing key seed traits in Perilla frutescens.BMC plant biology · 2025Article
- SPOROCYTELESS/NOZZLE cooperates with MADS-domain transcription factors to regulate an auxin-dependent network controlling Megaspore-Mother-Cell differentiation.Nature communications · 2025Article
- Structural Variants Contribute to Phenotypic Variation in Maize.Molecular ecology · 2025Article
- Functional characterization of CsSTK in floral organ development and its positive regulation by CsBPC5 in tea plants.BMC plant biology · 2025Article
- AnPlants (Basel, Switzerland) · 2025Article
- Auxin Orchestrates Germ Cell Specification inInternational journal of molecular sciences · 2025Review
- Identification of the MADS-Box Gene Family and the Key Role ofInternational journal of molecular sciences · 2025Article
- The MADS-box protein SHATTERPROOF 2 regulates TAA1 expression in the gynoecium valve margins.Plant reproduction · 2025Article
- Article
- Structural variants contribute to phenotypic variation in maize.bioRxiv : the preprint server for biology · 2024Article
- Auxin response factor 10 insensitive to miR160regulation induces apospory-like phenotypes iniScience · 2024Article
- Transcriptomic landscape of seedstick in Arabidopsis thaliana funiculus after fertilisation.BMC plant biology · 2024Article
- Germline β-1,3-glucan deposits are required for female gametogenesis in Arabidopsis thaliana.Nature communications · 2024Article
- Genome-Wide Analysis of MADS-Box Gene Family RevealsInternational journal of molecular sciences · 2024Article
- Dynamic metabolite QTL analyses provide novel biochemical insights into kernel development and nutritional quality improvement in common wheat.Plant communications · 2024Article
- HISTONE DEACETYLASE19 Controls Ovule Number Determination and Transmitting Tract Differentiation.Plant physiology · 2024Article
- The APETALA2-MYBL2 module represses proanthocyanidin biosynthesis by affecting formation of the MBW complex in seeds of Arabidopsis thaliana.Plant communications · 2024Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of secondary metabolites in the determination of cell identity has been an area of particular interest over recent years, and studies strongly indicate a connection between cell fate and the regulation of enzymes involved in secondary metabolism. In Arabidopsis thaliana, the maternally derived seed coat plays pivotal roles in both the protection of the developing embryo and the first steps of germination. In this regard, a characteristic feature of seed coat development is the accumulation of proanthocyanidins (PAs - a class of phenylpropanoid metabolites) in the innermost layer of the seed coat. Our genome-wide transcriptomic analysis suggests that the ovule identity factor SEEDSTICK (STK) is involved in the regulation of several metabolic processes, providing a strong basis for a connection between cell fate determination, development and metabolism. Using phenotypic, genetic, biochemical and transcriptomic approaches, we have focused specifically on the role of STK in PA biosynthesis. Our results indicate that STK exerts its effect by direct regulation of the gene encoding BANYULS/ANTHOCYANIDIN REDUCTASE (BAN/ANR), which converts anthocyanidins into their corresponding 2,3-cis-flavan-3-ols. Our study also demonstrates that the levels of H3K9ac chromatin modification directly correlate with the active state of BAN in an STK-dependent way. This is consistent with the idea that MADS-domain proteins control the expression of their target genes through the modification of chromatin states. STK might thus recruit or regulate histone modifying factors to control their activity. In addition, we show that STK is able to regulate other BAN regulators. Our study demonstrates for the first time how a floral homeotic gene controls tissue identity through the regulation of a wide range of processes including the accumulation of secondary metabolites.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.