ArticleNeuron2014
Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Translational modulator ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome.iScience · 2024Article
- Directly reprogrammed fragile X syndrome dorsal forebrain precursor cells generate cortical neurons exhibiting impaired neuronal maturation.Frontiers in cellular neuroscience · 2023Article
- Combined DiI and Antibody Labeling Reveals Complex Dysgenesis of Hippocampal Dendritic Spines in a Mouse Model of Fragile X Syndrome.Biomedicines · 2022Article
- Hyperexcitable arousal circuits drive sleep instability during aging.Science (New York, N.Y.) · 2022Article
- FMRP regulates the subcellular distribution of cortical dendritic spine density in a non-cell-autonomous manner.Neurobiology of disease · 2021Article
- The synapse in traumatic brain injury.Brain : a journal of neurology · 2021Review
- Synapse diversity and synaptome architecture in human genetic disorders.Human molecular genetics · 2019Review
- Altered dendritic spine function and integration in a mouse model of fragile X syndrome.Nature communications · 2019Article
- Multifaceted Changes in Synaptic Composition and Astrocytic Involvement in a Mouse Model of Fragile X Syndrome.Scientific reports · 2019Article
- Spectral Analysis of Codons in the DNA Sequence of Fragile X Syndrome.Journal of medical systems · 2019Article
- Local cortical circuit correlates of altered EEG in the mouse model of Fragile X syndrome.Neurobiology of disease · 2019Article
- Regulation of IL-6 Secretion by Astrocytes via TLR4 in the Fragile X Mouse Model.Frontiers in molecular neuroscience · 2018Article
- Altered Developmental Expression of the Astrocyte-Secreted Factors Hevin and SPARC in the Fragile X Mouse Model.Frontiers in molecular neuroscience · 2017Article
- Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized ineLife · 2016Article
- Unbiased, High-Throughput Electron Microscopy Analysis of Experience-Dependent Synaptic Changes in the Neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish.PLoS genetics · 2015Article
- GABAB receptor-mediated feed-forward circuit dysfunction in the mouse model of fragile X syndrome.The Journal of physiology · 2015Article
- Review
- Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and Back.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- mGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal Cortex.CNS & neurological disorders drug targets · 2015Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Cognitive deficits in fragile X syndrome (FXS) are attributed to molecular abnormalities of the brain's vast and heterogeneous synapse populations. Unfortunately, the density of synapses coupled with their molecular heterogeneity presents formidable challenges in understanding the specific contribution of synapse changes in FXS. We demonstrate powerful new methods for the large-scale molecular analysis of individual synapses that allow quantification of numerous specific changes in synapse populations present in the cortex of a mouse model of FXS. Analysis of nearly a million individual synapses reveals distinct, quantitative changes in synaptic proteins distributed across over 6,000 pairwise metrics. Some, but not all, of these synaptic alterations are reversed by treatment with the candidate therapeutic fenobam, an mGluR5 antagonist. These patterns of widespread, but diverse synaptic protein changes in response to global perturbation suggest that FXS and its treatment must be understood as a networked system at the synapse level.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.