ArticleBMC bioinformatics2014
Bhageerath-H: a homology/ab initio hybrid server for predicting tertiary structures of monomeric soluble proteins.
Article in BMC bioinformatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
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- Subtractive Proteomics and Reverse-Vaccinology Approaches for Novel Drug Target Identification and Chimeric Vaccine Development againstBioengineering (Basel, Switzerland) · 2024Article
- Genome mining ofFrontiers in microbiology · 2024Article
- Role of environmental specificity in CASP results.BMC bioinformatics · 2023Article
- Molecular docking in organic, inorganic, and hybrid systems: a tutorial review.Monatshefte fur chemie · 2023Review
- Application of Mathematical Modeling and Computational Tools in the Modern Drug Design and Development Process.Molecules (Basel, Switzerland) · 2022Review
- Plant Source Derived Compound ExhibitedFrontiers in pharmacology · 2022Article
- Improved 3-D Protein Structure Predictions using Deep ResNet Model.The protein journal · 2021Article
- Protein Structure Prediction: Conventional and Deep Learning Perspectives.The protein journal · 2021Review
- A novel piperazine derivative that targets hepatitis B surface antigen effectively inhibits tenofovir resistant hepatitis B virus.Scientific reports · 2021Article
- PvP01-DB: computational structural and functional characterization of soluble proteome of PvP01 strain of Plasmodium vivax.Database : the journal of biological databases and curation · 2020Article
- Molecular Interaction between Distal C-Terminal Domain of the CBJournal of chemical information and modeling · 2019Article
- The effect of amantadine on an ion channel protein from Chikungunya virus.PLoS neglected tropical diseases · 2019Article
- Identification and analysis of structurally critical fragments in HopS2.BMC bioinformatics · 2019Article
- PvaxDB: a comprehensive structural repository of Plasmodium vivax proteome.Database : the journal of biological databases and curation · 2018Article
- In Silico evaluation and identification of fungi capable of producing endo-inulinase enzyme.PloS one · 2018Article
- The VP4 peptide of hepatitis A virus ruptures membranes through formation of discrete pores.Journal of virology · 2014Article
- InCoB2014: bioinformatics to tackle the data to knowledge challenge. Introduction.BMC bioinformatics · 2014Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe advent of human genome sequencing project has led to a spurt in the number of protein sequences in the databanks. Success of structure based drug discovery severely hinges on the availability of structures. Despite significant progresses in the area of experimental protein structure determination, the sequence-structure gap is continually widening. Data driven homology based computational methods have proved successful in predicting tertiary structures for sequences sharing medium to high sequence similarities. With dwindling similarities of query sequences, advanced homology/ ab initio hybrid approaches are being explored to solve structure prediction problem. Here we describe Bhageerath-H, a homology/ ab initio hybrid software/server for predicting protein tertiary structures with advancing drug design attempts as one of the goals.
resultsBhageerath-H web-server was validated on 75 CASP10 targets which showed TM-scores ≥ 0.5 in 91% of the cases and Cα RMSDs ≤ 5 Å from the native in 58% of the targets, which is well above the CASP10 water mark. Comparison with some leading servers demonstrated the uniqueness of the hybrid methodology in effectively sampling conformational space, scoring best decoys and refining low resolution models to high and medium resolution.
conclusionBhageerath-H methodology is web enabled for the scientific community as a freely accessible web server. The methodology is fielded in the on-going CASP11 experiment.
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