ArticleZebrafish2015
Whole-body imaging of a hypercholesterolemic female zebrafish by using synchrotron X-ray micro-CT.
Article in Zebrafish, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Development of the zebrafish foveal analogue: a quantitative atlas of high-acuity zone growth and retinal regionalisation.Biology open · 2026Article
- A wide-field micro-computed tomography detector: micron resolution at half-centimetre scale.Journal of synchrotron radiation · 2022Article
- Intact in vivo visualization of telencephalic microvasculature in medaka using optical coherence tomography.Scientific reports · 2020Article
- Article
- Three-dimensional NMR microscopy of zebrafish specimens.NMR in biomedicine · 2019Article
- Assessment of high-fat-diet-induced fatty liver in medaka.Biology open · 2018Article
- Rigid Embedding of Fixed and Stained, Whole, Millimeter-Scale Specimens for Section-free 3D Histology by Micro-Computed Tomography.Journal of visualized experiments : JoVE · 2018Article
- X-ray computed tomography and its potential in ecological research: A review of studies and optimization of specimen preparation.Ecology and evolution · 2018Review
- Label-free photoacoustic imaging of the cardio-cerebrovascular development in the embryonic zebrafish.Biomedical optics express · 2017Article
- Whole-body multispectral photoacoustic imaging of adult zebrafish.Biomedical optics express · 2016Article
- Zebrafish: A complete animal model to enumerate the nanoparticle toxicity.Journal of nanobiotechnology · 2016Review
- Exploring miniature insect brains using micro-CT scanning techniques.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zebrafish has been used as a powerful model system in biological and biomedical studies studying development and diseases. Comparative, functional, and developmental studies on zebrafish morphology require precise visualization of 3D morphological structures. Few methods that can visualize whole-volume of zebrafish tissues are available because optical bio-imaging methods are limited by pigmentation and hard tissues. To overcome these limitations, the 3D microstructures of a hypercholesterolemic zebrafish model are visualized using synchrotron X-ray micro-computed tomography (SR-μCT). The model spatial resolution ranged from sub- to several microns. The microstructures of various zebrafish organs are observed by combining high-contrast staining (osmium tetroxide and uranyl acetate) and embedding a protocol to enhance the image contrast of soft tissues. Furthermore, blood vessels are identified using a barium sulfate injection technique. The internal organs and cells, such as liver, intestine, oocytes, and adipocytes, of a hypercholesterolemic zebrafish are compared with those of normal organs and cells. The SR-μCT is useful for understanding the pathogenesis of circulatory vascular diseases by detecting the modifications in the 3D morphological structures of the whole body of the zebrafish. This bio-imaging technique can be readily used to study other disease models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.