Evidence map›Paper›PMID 25521230›Full record

ArticleBMC medical informatics and decision making2014

A community assessment of privacy preserving techniques for human genomes.

Xiaoqian Jiang, Yongan Zhao, Xiaofeng Wang, Bradley Malin, Shuang Wang, Lucila Ohno-Machado, Haixu Tang

Open access · goldAbstract read
In one paragraph

Article in BMC medical informatics and decision making, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. A secure system for genomics clinical decision support.Journal of biomedical informatics · 2020
    Article
  3. Protecting Genomic Data Privacy with Probabilistic Modeling.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2019
    Article
  4. When Biology Gets Personal: Hidden Challenges of Privacy and Ethics in Biological Big Data.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2019
    Article
  5. Article
  6. Secure Outsourced Matrix Computation and Application to Neural Networks.Conference on Computer and Communications Security : proceedings of the ... conference on computer and communications security. ACM Conference on Computer and Communications Security · 2018
    Article
  7. Article
  8. Privacy Policy and Technology in Biomedical Data Science.Annual review of biomedical data science · 2018
    Article
  9. A Secure Alignment Algorithm for Mapping Short Reads to Human Genome.Journal of computational biology : a journal of computational molecular cell biology · 2018
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. SCOTCH: Secure Counting Of encrypTed genomiC data using a Hybrid approach.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2017
    Article
  17. Review
  18. Article
  19. Article
  20. An informatics research agenda to support precision medicine: seven key areas.Journal of the American Medical Informatics Association : JAMIA · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Xiaoqian Jiang
Yongan Zhao
Xiaofeng Wang
Bradley Malin
Shuang Wang
Lucila Ohno-Machado
Haixu Tang
University of California, San Diego · USIndiana University · USIndiana University Bloomington · USVanderbilt University · US

Funding

San Diego Clinical and Translational Research InstituteUL1TR000100 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2015
$19.7M
iDASH: Integrating Data for Analysis, Anonymization, and SharingU54HL108460 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OHNO-MACHADO, LUCILA · 2010 to 2015
$19.1M
Privacy preserving technologies for human genome data analysis and disseminationR01HG007078 · NHGRI · TRUSTEES OF INDIANA UNIVERSITY · PI TANG, HAIXU, WANG, XIAOFENG · 2013 to 2015
$886k
Protection of Records: Privacy (PReP) Technology for Medical ResearchR00LM011392 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIANG, XIAOQIAN · 2013 to 2015
$650k
Protect Privacy of Healthcare Data in the CloudR21LM012060 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIANG, XIAOQIAN · 2014 to 2015
$376k
Protecting the pRivacy Of Genomes in Research StudieS (PROGRESS)K99HG008175 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, SHUANG · 2014 to 2015
$100k
NCATS NIH HHS UL1TR000100NHGRI NIH HHS K99 HG008175NHGRI NIH HHS K99HG008175NHGRI NIH HHS R01 HG007078NHGRI NIH HHS R01HG007078NHLBI NIH HHS U54HL108460NLM NIH HHS R00 LM011392NLM NIH HHS R00LM011392NLM NIH HHS R21 LM012060NLM NIH HHS R21LM012060
6 · The paper itself

Abstract

To answer the need for the rigorous protection of biomedical data, we organized the Critical Assessment of Data Privacy and Protection initiative as a community effort to evaluate privacy-preserving dissemination techniques for biomedical data. We focused on the challenge of sharing aggregate human genomic data (e.g., allele frequencies) in a way that preserves the privacy of the data donors, without undermining the utility of genome-wide association studies (GWAS) or impeding their dissemination. Specifically, we designed two problems for disseminating the raw data and the analysis outcome, respectively, based on publicly available data from HapMap and from the Personal Genome Project. A total of six teams participated in the challenges. The final results were presented at a workshop of the iDASH (integrating Data for Analysis, 'anonymization,' and SHaring) National Center for Biomedical Computing. We report the results of the challenge and our findings about the current genome privacy protection techniques.

Indexed as

Information DisseminationGenetic PrivacyGenome-Wide Association StudyHumans

Identifiers

PMID25521230
PMCPMC4290799
OpenAlexW2040807773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.