ArticleCell proliferation2015
Effects of anodic titanium dioxide nanotubes of different diameters on macrophage secretion and expression of cytokines and chemokines.
Article in Cell proliferation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- A clinically translatable coating-free strategy for 3D-printed porous titanium implants: TiOBioactive materials · 2026Article
- Rational design of immunological programs for functional regenerative niches.Materials today. Bio · 2026Review
- Inducing macrophage M2-Type polarization via anodized anisotropic TiOBMC oral health · 2025Article
- Regulation of immune microenvironments by polyetheretherketone surface topography for improving osseointegration.Journal of nanobiotechnology · 2025Article
- Tanfloc-Modified Titanium Surfaces: Optimizing Blood Coagulant Activity and Stem Cell Compatibility.ACS biomaterials science & engineering · 2025Article
- Machine Learning Approach to Investigating Macrophage Polarization on Various Titanium Surface Characteristics.BME frontiers · 2025Article
- Review
- Inflammatory or Reparative? Tuning Macrophage Polarization Using Anodized Anisotropic Nanoporous Titanium Implant Surfaces.Small science · 2024Article
- A submicron forest-like silicon surface promotes bone regeneration by regulating macrophage polarization.Frontiers in bioengineering and biotechnology · 2024Article
- Silk Fibroin/ZnO Coated TiOMaterials (Basel, Switzerland) · 2023Article
- Chirality-biased protein expression profile during early stages of bone regeneration.Frontiers in bioengineering and biotechnology · 2023Article
- Localised Delivery of Cisplatin from Chitosan-Coated Titania Nanotube Array Nanosystems Targeting Nasopharyngeal Carcinoma.Advanced pharmaceutical bulletin · 2023Article
- Nanotopographical cues for regulation of macrophages and osteoclasts: emerging opportunities for osseointegration.Journal of nanobiotechnology · 2022Review
- Molecular Response to Nanopatterned Implants in the Human Jaw Bone.ACS biomaterials science & engineering · 2021Article
- Titanium dioxide nanotubes promote M2 polarization by inhibiting macrophage glycolysis and ultimately accelerate endothelialization.Immunity, inflammation and disease · 2021Article
- Deciphering controversial results of cell proliferation on TiORegenerative biomaterials · 2021Article
- Article
- Suitability of Different Titanium Dioxide Nanotube Morphologies for Photocatalytic Water Treatment.Nanomaterials (Basel, Switzerland) · 2021Article
- Titanium Wear of Dental Implants from Placement, under Loading and Maintenance Protocols.International journal of molecular sciences · 2021Review
- Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration.Regenerative biomaterials · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate effects of TiO2 nanotubes of different diameters on J744A.1 macrophage behaviour, secretion and expression of pro-inflammatory cytokines and chemokines. MATERIALS AND
methodsMacrophage-like J744A.1 cells were cultured on three types of Ti surface: mechanically polished titanium plus 30 and 80 nm TiO2 nanotube surfaces, for 4, 24 and 48 h. Macrophage adhesion and proliferation were assessed using CCK-8 assay. Levels of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) and chemokines (MCP-1 and MIP-1α) secreted into the supernatant were measured using the Cytometric Bead Arrays kit. TNF-α, MCP-1 and MIP-1α gene expression were quantitatively analysed by real-time PCR.
resultsThese show that TiO2 nanotube surfaces, especially of 80 nm TiO2 nanotube, benefited macrophage adhesion and proliferation, and reduced protein secretion and mRNA expression of TNF-α, MCP-1 and MIP-1α. IL-1β and IL-6 were undetectable on all the surfaces at all times.
conclusionsTiO2 nanotube surfaces, especially of 80 nm TiO2 nanotube, reduced inflammatory response in vitro, which might be part of a basis for rapid osseointegration in implants with TiO2 nanotube surfaces in animal studies.
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