Evidence map›Paper›PMID 25521188›Full record

Trial reportMaternal & child nutrition2015

Comparison of methods to assess adherence to small-quantity lipid-based nutrient supplements (SQ-LNS) and dispersible tablets among young Burkinabé children participating in a community-based intervention trial.

Souheila Abbeddou, Sonja Y Hess, Elizabeth Yakes Jimenez, Jérôme W Somé, Stephen A Vosti, Rosemonde M Guissou, Jean-Bosco Ouédraogo, Kenneth H Brown

2 registry-linked trialsOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in Maternal & child nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00944281 nacompletednot on this map

A Randomized, Double-blind, Controlled Trial in Rural Burkina Faso to Determine the Optimal Amount of Zinc to Include in a Lipid-based Nutrient Supplement (LNS). Part of the iLiNS Study

TypeinterventionalSponsorUniversity of California, DavisRan2010 to 2014Enrolled3,220ConditionsMalnutritionArmsLNS-Zn5, LNS-Zn10, LNS-Zn0, Suppl-Zn5
NCT07540793 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of 7-day vs 1-day Packaging of Small Quantity Lipid-based Nutrition Supplementation (SQ-LNS)

TypeinterventionalSponsorUniversity of California, San FranciscoRan2026 to 2026Enrolled100ConditionsPrevention, Malnutrition, Child, NutritionArms7dp SQ-LNS, 1dp SQ-LNS
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Souheila AbbeddouProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, California, USA.
Sonja Y HessProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, California, USA.
Elizabeth Yakes JimenezNutrition/Dietetics Program, Departments of Individual, Family and Community Education and Family and Community Medicine, University of New Mexico, Albuquerque, New Mexico, USA.
Jérôme W SoméProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, California, USA.
Stephen A VostiDepartment of Agricultural & Resource Economics, University of California, Davis, California, USA.
Rosemonde M GuissouInstitut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.
Jean-Bosco OuédraogoInstitut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.
Kenneth H BrownProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, California, USA.
University of California, Davis · USInstitut de Recherche en Sciences de la Santé · BFUniversity of New Mexico · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adherence to supplementation provided during an intervention trial can affect interpretation of study outcomes. We compared different approaches for estimating adherence to small-quantity lipid-based nutrient supplements (SQ-LNS) and dispersible tablets in a randomised clinical trial in Burkina Faso. A total of 2435 children (9-18 months) were randomly assigned to receive daily 20 g SQ-LNS with varying contents of zinc and a dispersible tablet containing 0 or 5 mg zinc. Adherence to SQ-LNS and tablets was assessed for all children through weekly caregiver interviews, and disappearance rate was calculated based on empty and unused packages returned during home visits. Additional adherence data were collected in different randomly selected subgroups of children: 12-h home observations were completed for children 11 and 16 months of age (n = 192) to assess consumption of SQ-LNS and dispersible tablets, and plasma zinc concentration was measured at baseline and 18 months (n = 310). Apparent adherence to SQ-LNS and dispersible tablets differed according to the assessment method used. Average daily caregiver-reported adherence to both SQ-LNS and dispersible tablets was 97 ± 6%. Disappearance rates showed similarly high average weekly adherence (98 ± 4%). In contrast, only 63% and 54% of children at 11 and 16 months, respectively, received SQ-LNS during the 12-h home observation periods, and fewer (32% and 27%) received a tablet. The lack of change in plasma zinc concentration after 9 months of supplementation suggests low adherence to the zinc tablet. Better methods are needed to assess adherence in community-based supplementation trials.

Indexed as

Dietary SupplementsPatient ComplianceBurkina FasoDietary FatsDose-Response Relationship, DrugDouble-Blind MethodHumansInfantLogistic ModelsRural PopulationSocioeconomic FactorsTabletsZincDietary FatsTabletsZincadherenceBurkina Fasocaregiversdisappearance ratehome observationinfantsplasma zinc concentrationreportsmall-quantity lipid-based nutrient supplementszinc

Identifiers

PMID25521188
PMCPMC6860357
OpenAlexW2150192644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.