Evidence map›Paper›PMID 25521168›Full record

Observational studyDrug and alcohol review2015

Denial of prescription analgesia among people who inject drugs in a Canadian setting.

Pauline Voon, Cody Callon, Paul Nguyen, Sabina Dobrer, Julio S G Montaner, Evan Wood, Thomas Kerr

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Drug and alcohol review, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 58 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. The effects of a provincial opioid prescribing standard on prescribing for pain in adults: an interrupted time-series analysis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
  7. Article
  8. Chronic pain and accidental acute toxicity deaths in Canada, 2016-2017.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Pauline VoonBritish Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Vancouver, Canada.
Cody Callon
Paul Nguyen
Sabina Dobrer
Julio S G Montaner
Evan Wood
Thomas Kerr
St. Paul's Hospital · CASt. Paul's Hospital · CAUniversity of British Columbia · CA

Funding

Vancouver Drug Users Study: The Impacts of Evolving Drug Use Patterns on HIV/AIDSU01DA038886 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI DEBECK, KORA, HAYASHI, KANNA · 2015 to 2024
$12.1M
SYRINGE ACCESS AND RISK FACTORS ON HIV TRANSMISSIONR01DA011591 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI KERR, THOMAS · 1998 to 2014
$5.9M
Impacts of universal access to HIV/AIDS care among HIV+ injection drug usersR01DA021525 · NIDA · UNIVERSITY OF BRITISH COLUMBIA · PI MILLOY, M-J · 2007 to 2016
$5.8M
NIDA NIH HHS R01 DA011591NIDA NIH HHS R01DA011591NIDA NIH HHS R01 DA021525NIDA NIH HHS R01DA021525NIDA NIH HHS U01 DA038886
6 · The paper itself

Abstract

INTRODUCTION AND

aimsDespite the high prevalence of pain among people who inject drugs (PWIDs), clinicians may be reluctant to prescribe opioid-based analgesia to those with a history of drug use or addiction. We sought to examine the prevalence and correlates of PWIDs reporting being denied of prescription analgesia (PA). We also explored reported reasons for and actions taken after being denied PA. DESIGN AND

methodsUsing data from two prospective cohort studies of PWIDs, multivariate logistic regression was used to identify the prevalence and correlates of reporting being denied PA. Descriptive statistics were used to characterise reasons for denials and subsequent actions.

resultsApproximately two-thirds (66.5%) of our sample of 462 active PWIDs reported having ever been denied PA. We found that reporting being denied PA was significantly and positively associated with having ever been enrolled in methadone maintenance treatment (adjusted odds ratio 1.76, 95% confidence interval 1.11-2.80) and daily cocaine injection (adjusted odds ratio 2.38, 95% confidence interval 1.00-5.66). The most commonly reported reason for being denied PA was being accused of drug seeking (44.0%). Commonly reported actions taken after being denied PA included buying the requested medication off the street (40.1%) or obtaining heroin to treat pain (32.9%). DISCUSSION AND

conclusionsThese findings highlight the challenges of addressing perceived pain and the need for strategies to prevent high-risk methods of self-managing pain, such as obtaining diverted medications or illicit substances for pain. Such strategies may include integrated pain management guidelines within methadone maintenance treatment and other substance use treatment programs.

Indexed as

Self ReportAdultAnalgesics, OpioidCanadaCohort StudiesFemaleHumansMaleMiddle AgedPainPrescription Drug OveruseProspective StudiesSubstance Abuse, IntravenousAnalgesics, Opioiddiversiondrug seekingmethadonepainprescription opioid

Identifiers

PMID25521168
PMCPMC4657858
OpenAlexW1892507735

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.