Evidence map›Paper›PMID 25520956›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2014

CB1 receptor affects cortical plasticity and response to physiotherapy in multiple sclerosis.

Francesco Mori, Concetta Ljoka, Carolina G Nicoletti, Hajime Kusayanagi, Fabio Buttari, Laura Giordani, Silvia Rossi, Calogero Foti, Diego Centonze

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Francesco MoriClinica Neurologica (F.M., C.G.N., H.K., F.B., S.R., D.C.), Dipartimento di Medicina dei Sistemi, and Medicina Fisica e Riabilitativa (C.L., L.G., C.F.), Dipartimento di Sanità Pubblica e Biologia Cellulare, Università Tor Vergata, Rome, Italy; and Centro Europeo per la Ricerca sul Cervello (CERC)/Fondazione Santa Lucia (F.M., C.G.N., H.K., F.B., S.R., D.C.), Rome, Italy.
Concetta LjokaClinica Neurologica (F.M., C.G.N., H.K., F.B., S.R., D.C.), Dipartimento di Medicina dei Sistemi, and Medicina Fisica e Riabilitativa (C.L., L.G., C.F.), Dipartimento di Sanità Pubblica e Biologia Cellulare, Università Tor Vergata, Rome, Italy; and Centro Europeo per la Ricerca sul Cervello (CERC)/Fondazione Santa Lucia (F.M., C.G.N., H.K., F.B., S.R., D.C.), Rome, Italy.
Carolina G NicolettiClinica Neurologica (F.M., C.G.N., H.K., F.B., S.R., D.C.), Dipartimento di Medicina dei Sistemi, and Medicina Fisica e Riabilitativa (C.L., L.G., C.F.), Dipartimento di Sanità Pubblica e Biologia Cellulare, Università Tor Vergata, Rome, Italy; and Centro Europeo per la Ricerca sul Cervello (CERC)/Fondazione Santa Lucia (F.M., C.G.N., H.K., F.B., S.R., D.C.), Rome, Italy.
Hajime KusayanagiClinica Neurologica (F.M., C.G.N., H.K., F.B., S.R., D.C.), Dipartimento di Medicina dei Sistemi, and Medicina Fisica e Riabilitativa (C.L., L.G., C.F.), Dipartimento di Sanità Pubblica e Biologia Cellulare, Università Tor Vergata, Rome, Italy; and Centro Europeo per la Ricerca sul Cervello (CERC)/Fondazione Santa Lucia (F.M., C.G.N., H.K., F.B., S.R., D.C.), Rome, Italy.
Fabio ButtariClinica Neurologica (F.M., C.G.N., H.K., F.B., S.R., D.C.), Dipartimento di Medicina dei Sistemi, and Medicina Fisica e Riabilitativa (C.L., L.G., C.F.), Dipartimento di Sanità Pubblica e Biologia Cellulare, Università Tor Vergata, Rome, Italy; and Centro Europeo per la Ricerca sul Cervello (CERC)/Fondazione Santa Lucia (F.M., C.G.N., H.K., F.B., S.R., D.C.), Rome, Italy.
Laura GiordaniClinica Neurologica (F.M., C.G.N., H.K., F.B., S.R., D.C.), Dipartimento di Medicina dei Sistemi, and Medicina Fisica e Riabilitativa (C.L., L.G., C.F.), Dipartimento di Sanità Pubblica e Biologia Cellulare, Università Tor Vergata, Rome, Italy; and Centro Europeo per la Ricerca sul Cervello (CERC)/Fondazione Santa Lucia (F.M., C.G.N., H.K., F.B., S.R., D.C.), Rome, Italy.
Silvia RossiClinica Neurologica (F.M., C.G.N., H.K., F.B., S.R., D.C.), Dipartimento di Medicina dei Sistemi, and Medicina Fisica e Riabilitativa (C.L., L.G., C.F.), Dipartimento di Sanità Pubblica e Biologia Cellulare, Università Tor Vergata, Rome, Italy; and Centro Europeo per la Ricerca sul Cervello (CERC)/Fondazione Santa Lucia (F.M., C.G.N., H.K., F.B., S.R., D.C.), Rome, Italy.
Calogero FotiClinica Neurologica (F.M., C.G.N., H.K., F.B., S.R., D.C.), Dipartimento di Medicina dei Sistemi, and Medicina Fisica e Riabilitativa (C.L., L.G., C.F.), Dipartimento di Sanità Pubblica e Biologia Cellulare, Università Tor Vergata, Rome, Italy; and Centro Europeo per la Ricerca sul Cervello (CERC)/Fondazione Santa Lucia (F.M., C.G.N., H.K., F.B., S.R., D.C.), Rome, Italy.
Diego CentonzeClinica Neurologica (F.M., C.G.N., H.K., F.B., S.R., D.C.), Dipartimento di Medicina dei Sistemi, and Medicina Fisica e Riabilitativa (C.L., L.G., C.F.), Dipartimento di Sanità Pubblica e Biologia Cellulare, Università Tor Vergata, Rome, Italy; and Centro Europeo per la Ricerca sul Cervello (CERC)/Fondazione Santa Lucia (F.M., C.G.N., H.K., F.B., S.R., D.C.), Rome, Italy.
Fondazione Santa Lucia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTherapeutic effects of physical therapy in neurologic disorders mostly rely on the promotion of use-dependent synaptic plasticity in damaged neuronal circuits. Genetic differences affecting the efficiency of synaptic plasticity mechanisms could explain why some patients do not respond adequately to the treatment. It is known that physical exercise activates the endocannabinoid system and that stimulation of cannabinoid CB1 receptors (CB1Rs) promotes synaptic plasticity in both rodents and humans. We thus tested whether CB1R genetic variants affect responsiveness to exercise therapy.

methodsWe evaluated the effect of a genetic variant of the CB1R associated with reduced receptor expression (patients with long AAT trinucleotide short tandem repeats in the CNR1 gene) on long-term potentiation (LTP)-like cortical plasticity induced by transcranial magnetic theta burst stimulation (TBS) of the motor cortex and, in parallel, on clinical response to exercise therapy in patients with multiple sclerosis.

resultsWe found that patients with long AAT CNR1 repeats do not express TBS-induced LTP-like cortical plasticity and show poor clinical benefit after exercise therapy.

conclusionsOur results provide the first evidence that genetic differences within the CB1R may influence clinical responses to exercise therapy, and they strengthen the hypothesis that CB1Rs are involved in the regulation of synaptic plasticity and in the control of spasticity in humans. This information might be of great relevance for patient stratification and personalized rehabilitation treatment programs.

Identifiers

PMID25520956
PMCPMC4268035
OpenAlexW2122014046

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.