ReviewFrontiers in public health2014
Chagas' disease: an emergent urban zoonosis. The caracas valley (Venezuela) as an epidemiological model.
Review in Frontiers in public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Heterogeneity of Trypanosoma cruzi infection rates in vectors and animal reservoirs in Colombia: a systematic review and meta-analysis.Parasites & vectors · 2019Pooled it
- Chagas disease in Trinidad and Tobago - a call to action.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025Article
- Empowering communities through One Health and ArtScience: An innovative approach to combat Chagas disease in endemic areas of Minas Gerais, Brazil.Public health challenges · 2025Article
- First Report of Chagas Disease Vector Species Triatoma sanguisuga (Hemiptera: Reduviidae) Infected with Trypanosoma cruzi in Delaware.The American journal of tropical medicine and hygiene · 2024Article
- Triatomines in the city: A study of Rhodnius neglectus in Jaboticabal, São Paulo, Brazil, and its epidemiological implications.Revista da Sociedade Brasileira de Medicina Tropical · 2024Article
- Vector mapping and bloodmeal metabarcoding demonstrate risk of urban Chagas disease transmission in Caracas, Venezuela.PLoS neglected tropical diseases · 2023Article
- Transcriptomic analysis of the adaptation to prolonged starvation of the insect-dwellingFrontiers in cellular and infection microbiology · 2023Article
- Chronic Chagas Disease-the Potential Role of Reinfections in Cardiomyopathy Pathogenesis.Current heart failure reports · 2022Review
- The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity.International journal of molecular sciences · 2022Review
- Chagas disease in the context of the 2030 agenda: global warming and vectors.Memorias do Instituto Oswaldo Cruz · 2022Article
- In the heart of the city: Trypanosoma cruzi infection prevalence in rodents across New Orleans.Parasites & vectors · 2020Article
- Host Diversity and Origin of Zoonoses: The Ancient and the New.Animals : an open access journal from MDPI · 2020Review
- A Narrative Review of the Role of Economic Crisis on Health and Healthcare Infrastructure in Three Disparate National Environments.International journal of environmental research and public health · 2020Review
- Trypanosoma cruzi transmission dynamics in a synanthropic and domesticated host community.PLoS neglected tropical diseases · 2019Article
- Zoonotic Trypanosomes in Rats and Fleas of Venezuelan Slums.EcoHealth · 2019Article
- Acute Chagas disease in the state of Pará, Amazon Region: is it increasing?Memorias do Instituto Oswaldo Cruz · 2018Article
- Venezuela and its rising vector-borne neglected diseases.PLoS neglected tropical diseases · 2017Article
- Editorial: Emerging Zoonoses: Eco-Epidemiology, Involved Mechanisms, and Public Health Implications.Frontiers in public health · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The unprecedented emergence of important public health and veterinary zoonoses is usually a result of exponential population growth and globalization of human activities. I characterized Chagas' disease as an emergent zoonosis in the Caracas Valley (Venezuela) due to the following findings: the presence of reservoirs (Didelphis marsupialis, Rattus rattus) and vectors (Panstrongylus geniculatus, Panstrongylus rufotuberculatus) infected with Trypanosoma cruzi in urbanized or marginalized areas; the elevated contact between P. geniculatus and human beings detected by parasitological and molecular examinations of triatomine feces demonstrated the possibility of transmission risks; a study of outbreaks of urban Chagas' disease reported the first proven case of oral transmission of T. cruzi to human beings; the risk of transmission of glandular metacyclic stages from marsupials by experimental ocular and oral instillation; mice genitalia infected with T. cruzi contaminated blood resulted in the formation of amastigotes very close to the lumen suggesting that there may be a possibility of infection via their release into the urine and thence to the exterior; the ubiquitous histotropism and histopathology of T. cruzi was demonstrated using a mouse model; the presence of experimental T. cruzi pseudocysts in adipose, bone-cartilage, and eye tissue indicated a potential risk for transplants. Socio-sanitary programs that include improvements in housing, vector control, and access to medical treatment, as well as strategies aimed at combating social inequalities, poverty, and underdevelopment should be undertaken in those areas where zoonoses are most prevalent. Disciplines, such as Ecology, Epidemiology, Medical Entomology, Human and Veterinary Medicine, Environmental Studies, Public Health, Social and Political Studies, Immunology, Microbiology, and Pharmacology could all provide important contributions that aim to reduce the occurrence of factors governing the spread of emergent diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.