ArticleFrontiers in microbiology2014
Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India.
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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79 citing papers in PubMed.
- Trophic status strongly regulates nitrous oxide but not methane production in global freshwater lake sediments.Nature communications · 2026Article
- Antimicrobial Resistance in the Food Chain: Bridging Knowledge Gaps for Effective Detection and Control.Antibiotics (Basel, Switzerland) · 2026Review
- A One-Health Perspective of Antimicrobial Resistance (AMR): Human, Animals and Environmental Health.Life (Basel, Switzerland) · 2025Review
- Review
- Composition, Distribution and Mobility Potential of the Antibiotic Resistome in Sediments from the East China Sea Revealed by Metagenomic Analysis.Microorganisms · 2025Article
- Article
- Metagenomic assemblies tend to break around antibiotic resistance genes.BMC genomics · 2024Article
- Non-antibiotic pharmaceuticals are toxic against Escherichia coli with no evolution of cross-resistance to antibiotics.npj antimicrobials and resistance · 2024Article
- Article
- Metagenomic profiling of viral and microbial communities from the pox lesions of lumpy skin disease virus and sheeppox virus-infected hosts.Frontiers in veterinary science · 2024Article
- Metagenomic profiling of antibiotic resistance genes in Red Sea brine pools.Archives of microbiology · 2023Article
- Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains.Nature microbiology · 2023Article
- Identification and characterization of a novel chromosomal aminoglycoside 3'-Frontiers in microbiology · 2023Article
- Decoding the microbial universe with metagenomics: a brief insight.Frontiers in genetics · 2023Review
- Antibiotic geographies and access to medicines: Tracing the role of India's pharmaceutical industry in global trade.Social science & medicine (1982) · 2022Review
- Advocacy for Responsible Antibiotic Production and Use.Antibiotics (Basel, Switzerland) · 2022Article
- Inverse PCR-based detection reveal novel mobile genetic elements and their associated genes in the human oral metagenome.BMC oral health · 2022Article
- Swedish Efforts to Contain Antibiotic Resistance in the Environment-A Qualitative Study among Selected Stakeholders.Antibiotics (Basel, Switzerland) · 2022Article
- Antibiotic resistance in the environment.Nature reviews. Microbiology · 2022Review
- Intra- and interpopulation transposition of mobile genetic elements driven by antibiotic selection.Nature ecology & evolution · 2022Article
19 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
There is increasing evidence for an environmental origin of many antibiotic resistance genes. Consequently, it is important to identify environments of particular risk for selecting and maintaining such resistance factors. In this study, we described the diversity of antibiotic resistance genes in an Indian lake subjected to industrial pollution with fluoroquinolone antibiotics. We also assessed the genetic context of the identified resistance genes, to try to predict their genetic transferability. The lake harbored a wide range of resistance genes (81 identified gene types) against essentially every major class of antibiotics, as well as genes responsible for mobilization of genetic material. Resistance genes were estimated to be 7000 times more abundant than in a Swedish lake included for comparison, where only eight resistance genes were found. The sul2 and qnrD genes were the most common resistance genes in the Indian lake. Twenty-six known and 21 putative novel plasmids were recovered in the Indian lake metagenome, which, together with the genes found, indicate a large potential for horizontal gene transfer through conjugation. Interestingly, the microbial community of the lake still included a wide range of taxa, suggesting that, across most phyla, bacteria has adapted relatively well to this highly polluted environment. Based on the wide range and high abundance of known resistance factors we have detected, it is plausible that yet unrecognized resistance genes are also present in the lake. Thus, we conclude that environments polluted with waste from antibiotic manufacturing could be important reservoirs for mobile antibiotic resistance genes.
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