ReviewFrontiers in neural circuits2014
The sacral networks and neural pathways used to elicit lumbar motor rhythm in the rodent spinal cord.
Review in Frontiers in neural circuits, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Ascending propriospinal modulation of thoracic sympathetic preganglionic neurons during lumbar locomotor activity.Frontiers in neural circuits · 2026Article
- Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord.iScience · 2025Article
- Spinal interneurons of the lower urinary tract circuits.Autonomic neuroscience : basic & clinical · 2021Review
- Inhibition and Facilitation of the Spinal Locomotor Central Pattern Generator and Reflex Circuits by Somatosensory Feedback From the Lumbar and Perineal Regions After Spinal Cord Injury.Frontiers in neuroscience · 2021Review
- Direct evidence for decreased presynaptic inhibition evoked by PBSt group I muscle afferents after chronic SCI and recovery with step-training in rats.The Journal of physiology · 2020Article
- Propriospinal Neurons of L3-L4 Segments Involved in Control of the Rat External Urethral Sphincter.Neuroscience · 2020Article
- Fictive Scratching Patterns in Brain Cortex-Ablated, Midcollicular Decerebrate, and Spinal Cats.Frontiers in neural circuits · 2020Article
- Rostral lumbar segments are the key controllers of hindlimb locomotor rhythmicity in the adult spinal rat.Journal of neurophysiology · 2019Article
- Locomotor-related V3 interneurons initiate and coordinate muscles spasms after spinal cord injury.Journal of neurophysiology · 2019Article
- The Spinal Cord, Not to Be Forgotten: the Final Common Path for Development, Training and Recovery of Motor Function.Perspectives on behavior science · 2018Article
- Stepping responses to treadmill perturbations vary with severity of motor deficits in human SCI.Journal of neurophysiology · 2018Article
- Article
- Stimulation of 5-HT2A receptors recovers sensory responsiveness in acute spinal neonatal rats.Behavioral neuroscience · 2017Article
- Shaping the Output of Lumbar Flexor Motoneurons by Sacral Neuronal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identification of neural networks and pathways involved in activation and modulation of spinal central pattern generators (CPGs) in the absence of the descending control from the brain is important for further understanding of neural control of movement and for developing innovative therapeutic approaches to improve the mobility of spinal cord injury patients. Activation of the hindlimb innervating segments by sacrocaudal (SC) afferent input and by specific application of neurochemicals to the sacral networks is feasible in the isolated spinal cord preparation of the newborn rat. Here we review our recent studies of sacral relay neurons with lumbar projections and evaluate their role in linking the sacral and thoracolumbar (TL) networks during different motor behaviors. Our major findings show that: (1) heterogeneous groups of dorsal, intermediate and ventral sacral-neurons with ventral and lateral ascending funicular projections mediate the activation of the locomotor CPGs through sacral sensory input; and (2) rhythmic excitation of lumbar flexor motoneurons, produced by bath application of alpha-1 adrenoceptor agonists to the sacral segments is mediated exclusively by ventral clusters of sacral-neurons with lumbar projections through the ventral funiculus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.