Evidence map›Paper›PMID 25520558›Full record

ArticleMagnetic resonance insights2014

Damage to the optic chiasm in myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitis mice.

Sheryl L Herrera, Vanessa L Palmer, Heather Whittaker, Blair Cardigan Smith, Annie Kim, Angela E Schellenberg, Jonathan D Thiessen, Richard Buist, Marc R Del Bigio, Melanie Martin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance insights, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sheryl L HerreraPhysics and Astronomy, University of Manitoba, Winnipeg, Manitoba, Canada.
Vanessa L PalmerBiomedical Engineering Program, University of Manitoba, Winnipeg, Manitoba, Canada.
Heather WhittakerBiopsychology Program, University of Winnipeg, Winnipeg, Manitoba, Canada.
Blair Cardigan SmithPhysics, University of Winnipeg, Winnipeg, Manitoba, Canada.
Annie KimPharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada.
Angela E SchellenbergPharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. ; General Surgery, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Jonathan D ThiessenImaging Program, Lawson Health Research Institute, London, Ontario, Canada. ; Medical Biophysics, Western University, London, Ontario, Canada.
Richard BuistRadiology, University of Manitoba, Winnipeg, Manitoba, Canada.
Marc R Del BigioPathology, University of Manitoba, Winnipeg, Manitoba, Canada.
Melanie MartinPhysics and Astronomy, University of Manitoba, Winnipeg, Manitoba, Canada. ; Biomedical Engineering Program, University of Manitoba, Winnipeg, Manitoba, Canada. ; Physics, University of Winnipeg, Winnipeg, Manitoba, Canada. ; Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. ; Radiology, University of Manitoba, Winnipeg, Manitoba, Canada.
University of Manitoba · CALawson Health Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optic chiasm lesions in myelin oligodendrocyte glycoprotein (MOG)-experimental autoimmune encephalomyelitis (EAE) mice were characterized using magnetic resonance imaging (MRI) and validated using electron microscopy (EM). MR images were collected from 3 days after induction to remission, approximately 20 days after induction. Hematoxylin and eosin, solochrome cyanin-stained sections, and EM images were obtained from the optic chiasms of some mice approximately 4 days after disease onset when their scores were thought to be the highest. T2-weighted imaging and apparent diffusion coefficient map hyperintensities corresponded to abnormalities in the optic chiasms of EAE mice. Mixed inflammation was concentrated at the lateral surface. Degeneration of oligodendrocytes, myelin, and early axonal damage were also apparent. A marked increase in chiasm thickness was observed. T2-weighted and diffusion-weighted MRI can detect abnormalities in the optic chiasms of MOG-EAE mice. MRI is an important method in the study of this model toward understanding optic neuritis.

Indexed as

experimental autoimmune encephalomyelitismagnetic resonance imagingmouseoptic chiasmpertussis toxin

Identifiers

PMID25520558
PMCPMC4226389
OpenAlexW2092382933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.