ArticleJournal of neurophysiology2015
Adult spinal V2a interneurons show increased excitability and serotonin-dependent bistability.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Biologically-constrained spiking neural network for neuromodulation in locomotor recovery after spinal cord injury.PLoS computational biology · 2026Article
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- Properties of rhythmogenic currents in spinal Shox2 interneurons across postnatal development.The Journal of physiology · 2025Article
- The spinal premotor network driving scratching flexor and extensor alternation.bioRxiv : the preprint server for biology · 2025Article
- Sodium-mediated plateau potentials in an identified decisional neuron contribute to feeding-related motor pattern genesis inFrontiers in neural circuits · 2023Article
- Transformation of an early-established motor circuit during maturation in zebrafish.Cell reports · 2022Article
- Identification of adult spinal Shox2 neuronal subpopulations based on unbiased computational clustering of electrophysiological properties.Frontiers in neural circuits · 2022Article
- Recruitment of Motoneurons.Advances in neurobiology · 2022Article
- Toward Assessing the Functional Connectivity of Spinal Neurons.Frontiers in neural circuits · 2022Article
- Spinal Cord Injury Alters Spinal Shox2 Interneurons by Enhancing Excitatory Synaptic Input and Serotonergic Modulation While Maintaining Intrinsic Properties in Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- A dynamic role for dopamine receptors in the control of mammalian spinal networks.Scientific reports · 2020Article
- The serotonin reuptake blocker citalopram destabilizes fictive locomotor activity in salamander axial circuits through 5-HTJournal of neurophysiology · 2020Article
- Serotonergic Modulation of Locomotor Activity From Basal Vertebrates to Mammals.Frontiers in neural circuits · 2020Review
- Exogenous neuromodulation of spinal neurons induces beta-band coherence during self-sustained discharge of hind limb motor unit populations.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Afterdischarges of Spinal Interneurons Following a Brief High-Frequency Stimulation of Ia Afferents in the Cat.Frontiers in integrative neuroscience · 2019Article
- Article
- Retracing your footsteps: developmental insights to spinal network plasticity following injury.Journal of neurophysiology · 2018Review
- Rapid recovery and altered neurochemical dependence of locomotor central pattern generation following lumbar neonatal spinal cord injury.The Journal of physiology · 2018Article
- Scaling Our World View: How Monoamines Can Put Context Into Brain Circuitry.Frontiers in cellular neuroscience · 2018Article
- And yet it moves: Recovery of volitional control after spinal cord injury.Progress in neurobiology · 2018Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In mice, most studies of the organization of the spinal central pattern generator (CPG) for locomotion, and its component neuron classes, have been performed on neonatal [postnatal day (P)2-P4] animals. While the neonatal spinal cord can generate a basic locomotor pattern, it is often argued that the CPG network is in an immature form whose detailed properties mature with postnatal development. Here, we compare intrinsic properties and serotonergic modulation of the V2a class of excitatory spinal interneurons in behaviorally mature (older than P43) mice to those in neonatal mice. Using perforated patch recordings from genetically tagged V2a interneurons, we revealed an age-dependent increase in excitability. The input resistance increased, the rheobase values decreased, and the relation between injected current and firing frequency (F/I plot) showed higher excitability in the adult neurons, with almost all neurons firing tonically during a current step. The adult action potential (AP) properties became narrower and taller, and the AP threshold hyperpolarized. While in neonates the AP afterhyperpolarization was monophasic, most adult V2a interneurons showed a biphasic afterhyperpolarization. Serotonin increased excitability and depolarized most neonatal and adult V2a interneurons. However, in ∼30% of adult V2a interneurons, serotonin additionally elicited spontaneous intrinsic membrane potential bistability, resulting in alternations between hyperpolarized and depolarized states with a dramatically decreased membrane input resistance and facilitation of evoked plateau potentials. This was never seen in younger animals. Our findings indicate a significant postnatal development of the properties of locomotor-related V2a interneurons, which could alter their interpretation of synaptic inputs in the locomotor CPG.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.