ArticleProceedings. Biological sciences2015
Variation in Drosophila melanogaster central metabolic genes appears driven by natural selection both within and between populations.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- A cosmopolitan inversion facilitates seasonal adaptation in overwintering Drosophila.Genetics · 2024Pooled it
- Overwintering drives rapid adaptation in Drosophila with potential costs to insecticide resistance.Evolution; international journal of organic evolution · 2026Article
- Early life-stage thermal resilience is determined by climate-linked regulatory variation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Continent-wide differentiation of fitness traits and patterns of climate adaptation among European populations ofEvolution letters · 2025Article
- Clinal variation in natural populations of Drosophila melanogaster: An old debate about natural selection and neutral processes.Genetics and molecular biology · 2024Article
- Mitonuclear interactions modulate nutritional preference.Biology letters · 2023Article
- Genomes from historical Drosophila melanogaster specimens illuminate adaptive and demographic changes across more than 200 years of evolution.PLoS biology · 2023Article
- Seasonal variation in wing size and shape of Drosophila melanogaster reveals rapid adaptation to environmental changes.Scientific reports · 2022Article
- Wolbachia reduces virus infection in a natural population of Drosophila.Communications biology · 2021Article
- Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation ineLife · 2021Article
- Genomic Responses to Climate Change: Making the Most of theFrontiers in genetics · 2021Article
- Phenotypic plasticity, but not adaptive tracking, underlies seasonal variation in post-cold hardening freeze tolerance ofEcology and evolution · 2020Article
- Dietary choices are influenced by genotype, mating status, and sex inEcology and evolution · 2018Article
- Understanding Evolutionary Impacts of Seasonality: An Introduction to the Symposium.Integrative and comparative biology · 2017Article
- On the Long-term Stability of Clines in Some Metabolic Genes in Drosophila melanogaster.Scientific reports · 2017Article
- Molecular Inversion Probes for targeted resequencing in non-model organisms.Scientific reports · 2016Article
- Global Transcriptional Profiling of Diapause and Climatic Adaptation in Drosophila melanogaster.Molecular biology and evolution · 2016Article
- Effects of ambient and preceding temperatures and metabolic genes on flight metabolism in the Glanville fritillary butterfly.Journal of insect physiology · 2016Article
- Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction.Proceedings. Biological sciences · 2015Article
- Seasonal variation in life history traits in two Drosophila species.Journal of evolutionary biology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
In this report, we examine the hypothesis that the drivers of latitudinal selection observed in the eastern US Drosophila melanogaster populations are reiterated within seasons in a temperate orchard population in Pennsylvania, USA. Specifically, we ask whether alleles that are apparently favoured in northern populations are also favoured early in the spring, and decrease in frequency from the spring to autumn with the population expansion. We use SNP data collected for 46 metabolic genes and 128 SNPs representing the central metabolic pathway and examine for the aggregate SNP allele frequencies whether the association of allele change with latitude and that with increasing days of spring-autumn season are reversed. Testing by random permutation, we observe a highly significant negative correlation between these associations that is consistent with this expectation. This correlation is stronger when we confine our analysis to only those alleles that show significant latitudinal changes. This pattern is not caused by association with chromosomal inversions. When data are resampled using SNPs for amino acid change the relationship is not significant but is supported when SNPs associated with cis-expression are only considered. Our results suggest that climate factors driving latitudinal molecular variation in a metabolic pathway are related to those operating on a seasonal level within populations.
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